Discover and read the best of Twitter Threads about #hospitalized

Most recents (2)

This important study found a significantly elevated frequency of #SARS-CoV-2-specific TNF-α-producing CD8+ T cells in patients with pulmonary #LongCovid (PASC). PASC subjects experienced an average symptom duration of over 6 months: journals.plos.org/plospathogens/…
2/ This is how the authors interpret the finding: "This increased frequency could be detected in response to peptide pools of all the #viral structural proteins in comparison to the resolved #COVID-19 (RC) cohort.
3/ Interestingly, these T cells were also significantly higher in female PASC participants compared to males, which may contribute to the higher prevalence of PASC in #women
Read 10 tweets
Here, in 24 sick patients admitted to ICU for longer periods, #microbiome diversity tended to decrease dramatically 👉 and subjects’ gut microbiomes often became dominated by pathogenic #bacteria that cld be passed from patient to patient: ncbi.nlm.nih.gov/m/pubmed/31526… ImageImage
2/2 A key takeaway from the study is that, under conditions of imbalance/immunosuppression, #organisms already present in a patient can evolve to become a serious pathogenic threat (eg there is not necessarily a need for a “new” external #infection)
3/3 Similarly, this Stanford team studied the source of bloodstream #infections in #hospitalized + immunocompromised patients 👉 In many cases, the same strain of a particular bloodstream #pathogen was also identified in a patients’ gut microbiome: nature.com/articles/s4159… ImageImage
Read 4 tweets

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