Discover and read the best of Twitter Threads about #hottopicsneo2020
Most recents (16)
Next up in "New Approaches to Cooling" Deirdre Murray of @CUH_Cork discussing “Neurodevelopmental Outcomes after Mild HIE.” Read more about Prof. Murray and her work: infantcentre.ie/who-we-are-2/o…
#HotTopicsNeo2020 @HotTopicsNeo
#HotTopicsNeo2020 @HotTopicsNeo
Murray begins by defining the population discussed in her lecture: those with encephalopathy 2/2 perinatal asphyxia.
#HotTopicsNeo2020 @HotTopicsNeo
#HotTopicsNeo2020 @HotTopicsNeo
How do infants with different HIE severity grades perform on IQ testing at 5 years of age? Summary from:
pubmed.ncbi.nlm.nih.gov/27650049/, which includes additional outcomes measures.
Take home point: mild and moderate HIE infants similar.
#HotTopicsNeo2020 @HotTopicsNeo
pubmed.ncbi.nlm.nih.gov/27650049/, which includes additional outcomes measures.
Take home point: mild and moderate HIE infants similar.
#HotTopicsNeo2020 @HotTopicsNeo
Last in the Rx for BPD trio at #HotTopicsNeo2020: Dr. Reese Clark of @MEDNAX with: "What Drugs are we Using? Practice Variability and Potential Harm." Read more about Dr. Clark's distinguished care:
blog.mednax.com/mednax-neonato…
@HotTopicsNeo
blog.mednax.com/mednax-neonato…
@HotTopicsNeo
Reese: Talk to focus on steroid use. To begin, what postnatal steroids are we using? Dexamethasone and hydrocortisone most common systematic exposures, budenoside most common inhaled exposure.
#HotTopicsNeo2020 @HotTopicsNeo
#HotTopicsNeo2020 @HotTopicsNeo
The unstoppable pendulum of postnatal steroid use; data from @MEDNAX clinical data warehouse suggests use again on the rise.
#HotTopicsNeo2020 @HotTopicsNeo
#HotTopicsNeo2020 @HotTopicsNeo
Next up in #HotTopicsNeo2020: Erik Jensen of @ChildrensPhila discussing how the baseline risk of BPD impacts the number needed to treat when considering effective therapies.
chop.edu/doctors/jensen…
@HotTopicsNeo
chop.edu/doctors/jensen…
@HotTopicsNeo
Presentation builds on recently published report in @JPediatr: drugs to Prevent Bronchopulmonary Dysplasia: Effect of Baseline Risk on the Number Needed to Treat
jpeds.com/article/S0022-…
#HotTopicsNeo2020
jpeds.com/article/S0022-…
#HotTopicsNeo2020
From the last session on periviability at @HotTopicsNeo, let’s get the pulse of the #neoEBM community with a few surveys (thread) #HotTopicsNeo2020
What is the earliest gestational age, assuming dating is correct, where you (or your hospital) routinely offer active postnatal resuscitation if desired by the family
If an infant at 22-24 weeks GA has evidence of inadequate organ perfusion (low urine output, decreasing BP), what is your first line treatment:
First up in: "Pharmacotherapy for BPD: We Know Less than We Think We Do" at #HotTopicsNeo2020 is Dr. Gerri Baer (@thegerribaer), Team Leader for Neonatology @US_FDA, discussing "Challenges in Studying Drugs for BPD"
@HotTopicsNeo #neoEBM
@HotTopicsNeo #neoEBM
Baer: no (zero, zilch, none!) drugs approved in the USA to prevent or treat BPD.
Highlights various cohorts demonstrating the ongoing high burden of BPD:
#HotTopicsNeo2020 @HotTopicsNeo
Highlights various cohorts demonstrating the ongoing high burden of BPD:
#HotTopicsNeo2020 @HotTopicsNeo
Baer: broad view of challenges to BPD Rx, illustrated by 3 buckets: understanding phenotypes/endotypes, definitions and classification and choosing adequate endpoints.
#HotTopicsNeo2020 @HotTopicsNeo
#HotTopicsNeo2020 @HotTopicsNeo
Dr. Mikael Norman discuss care of periviable infants in Sweden #HotTopicsNeo2020
Changes in survival in Sweden, with survival at 22 weeks' gestation around 50% and increasing thereafter
Differences in respiratory support at 22 wk GA
22 wk: 100% mechanically ventilated, mean duration 47 d
26 wk: 1 or 3 mechanically ventilated, mean duration 2 d
22 wk: 100% mechanically ventilated, mean duration 47 d
26 wk: 1 or 3 mechanically ventilated, mean duration 2 d
Highlights that this is a grey zone, where parental desires should be support
There is a substantial variability in in active care approaches by gestational age among European countries
Dr. Joseph Kaempf shares data from a systematic review and meta-analysis on whether neurodevelopment outcomes are changing over time in extremely premature infants #HotTopicsNeo2020 #neoEBM
The objective of the review was to evaluate within NICU or within cohort trends in NDI over time
A total of 13 studies were included in analysis
The Jerold F Lucey Keynote lecture delivered by Martin Elliott #LuceyLectureship #HotTopicsNeo2020 Lies and Their Impact in Academic Medicine @HotTopicsNeo #neoEBM
Some recent liars have been caught - but not all. #HotTopicsNeo2020
A stark warning that in our day of 'hype', online presence, celebrity, and social media that we must still be discerning ; just as journalist Bosse Lindquist in the synthetic tracheal implant scandal. #HotTopicsNeo2020
So when deferred cord clamping is not thought to be feasible, is cord milking a suitable alternative in terms of severe IVH? #HotTopicsNeo2020 #neoEBM
And introducing the inaugural Impact Article of the Year - extremely closely contested by @NPEU_CTU @dsweetbelfast @JonDorling18 @drbretty (to name just a few!) and won by @NeoAnup and his team!#HotTopicsNeo2020 #neoEBM
Are we paying too much for too little? @VPrasadMDMPH discusses the use of nusinersen for spinal muscular atrophy #HotTopicsNeo2020 #neoEBM
Monthly costs for orphan drug prices for rare conditions
The cost for nusinersen, an intrathecal therapy for SMA, costs approximately $125,000 per dose
In discussing therapies for skeletal dysplasia, @mikebbober highlights these are a heterogeneous group of unique disorders #HotTopicsNeo2020 #neoEBM
Best-practice guidelines for delivery and evaluation of patients with skeletal dysplasia ajog.org/article/S0002-… and skeletaldysplasia.org
Trial for a new enzyme-replacement therapy (ENB-0040) for severe hypophosphatasia: nejm.org/doi/full/10.10…
LMA for neonates?
Dr. Trevisanuto @UniPadova shares evidence regarding its use for neonatal resuscitation. #HotTopicsNeo2020 #neoEBM
Dr. Trevisanuto @UniPadova shares evidence regarding its use for neonatal resuscitation. #HotTopicsNeo2020 #neoEBM
Potential advantages of LMA use in neonates
Situations were LMA may be warranted for use in neonates
Telemedicine for neonatal resuscitation? @jenfang0908 shares the opportunities #HotTopicsNeo2020 #neoEBM
Can technology and telemedicine help close the gap in the mortality disparity for inborn and outborn infants?
Dr. Fang conducted a simulated study where pediatric trainees were assigned to two groups, one with telemedicine support
Drs. Myra Wyckoff @UTSWNews and Jonathan Wyllie provide an update on @Ilcor_org guidelines for neonatal life support #HotTopicsNeo2020 #neoEBM
Here is a link to the summary of updated guidelines: ahajournals.org/doi/10.1161/CI…
Recommendation (weak) against routine direct laryngoscopy and tracheal suctioning for non-vigorous newborn infants delivered through meconium-stained amniotic fluid
