Discover and read the best of Twitter Threads about #hydroxychloroquine

Most recents (24)

It's time for a quick thread on the @WHO @Worldometers and @JohnsHopkins dataset that underpins the whole #covid19 #pandemic

Where does it come from and is it even real?
I presume that the average person thinks that "real time data" is just there, ready to be seen across the whole world.

Hospitals and laboratories don't work like that.

So how does it work?
So the individual goes along and gets a test. That means a swab is put in the nose, put into a medium then eventually transported to the lab.

Someone in the lab puts it into a machine and in most cases a PCR test is done.
Read 22 tweets
Il est désormais acquis que l'étude initiale du Pr Raoult sur l'#Hydroxychloroquine était fumeuse, et qu'elle a hélas eu des conséquences négatives sur cette crise, en France et ailleurs, en générant espoir irrationnel, parasitage et épuisement de la recherche. #COVID19
MAIS
Au delà, il faut aussi s'interroger rapidement sur les mécanismes de la publication scientifique.

Prenons un exemple récent, en l'espèce, cet article publié dans l'International Journal of Antimicrobial Agents sciencedirect.com/science/articl…
Cet article est une critique de @FritsRosendaal du fameux article "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial" publié dans la même revue, depuis le 20 mars online. sciencedirect.com/science/articl…
Read 16 tweets
🔥On demande fréquemment où on en est pour la prise en charge #COVID__19 #COVID19 #SARSCoV2

Pas de traitement spécifique spectaculaire mais importance majeure des soins standards de pneumopathie virale sévère

Voilà une humble mise au point à destination grand public.

👇1/n
2/ On sait maintenant que >95% des cas évoluent favorablement sans traitement
Pr ces formes bénignes importance ttt symptomatique + surveillance notamment si à risque d'aggravation (âge avancé, ATCD médicaux : diabète, obésité, etc.) + information précise

antibioclic.com/questionnaire/…
3/ Pour formes sévères nécessitant hospitalisation, le + important reste le standard de soins d'une pneumonie virale sévère à savoir oxygénothérapie / support ventilatoire à adapter à chaque patient, prévention complications, kiné respi, gestions des atteintes d'organes 2ndaires
Read 15 tweets
🔥In Other News🔥

A small summary of the past week.

Q Countdown, we are Currently at 10
June 28, 2020

Turkish National TV - Exposing the Hollywood and Elites
June 30, 2020

Prosecutors have ordered the seizure of documents and computers from the administrative offices of St. Peter’s Basilica in an apparent new investigation into financial irregularities in the Holy See.

apnews.com/2d128700b0b251…
Read 47 tweets
"La propagation de #Covid a causé des dommages monumentaux à la planète. Depuis Marseille, dans le sud de la France, Raoult a compliqué à l'extrême la gestion de la crise, a divisé la communauté scientifique, a remis en cause presque toutes les décisions prises"
"Raoult a disqualifié les procédures de protection et le système de santé, et a humilié les chercheurs. Il a créé un débat public intense et irrationnel, mêlant science et politique"
Read 17 tweets
🔥🔥Article glaçant: L’analyse des actions gouvernementales depuis le #Covid19 montre qu’en réalité, une des véritables intentions de la suppression des droits élémentaires du citoyen est «d'éliminer les vieux» trop coûteux en terme de retraites...suite ⬇️ agoravox.fr/tribune-libre/…
Le Dr Leo Alexander 1949: «C’est à partir de débuts insignifiants que les valeurs d’une société entière peuvent être renversées». Bien avant les nazis au pouvoir, un changement dans la culture médicale s’était déjà produit «ouvrant la voie avec une littérature sur l’euthanasie»⬇️
#Covid19 Pas de masques ni gels, ni assez de respirateurs, pas d’ouvertures de lits ni embauche de personnel, plan blanc bloquant l'aide des cliniques privées, mais dont les lits restent vides. «En même temps » une mise en scène théâtrale du président...⬇️ huffingtonpost.fr/entry/coronavi…
Read 17 tweets
Since #Hydroxychloroquine is trending, it's a good time to share some information I've been collecting about conflicts of interest involving studies on it.

Thread

1/x
One of the most underreported stories about the pandemic - and more generally as newsworthy information - is the repeated occurrence and influence of major conflicts of interest in the study of Hydroxychloroquine as a treatment for covid-19...

2/x
...specifically by people with financial ties to Gilead Sciences, the company that manufactures Remdesivir, a drug whose only major competition as a treatment for covid-19 right now is Hydroxychloroquine.

Below are several examples of such conflicts of interest.

3/x
Read 10 tweets
So remember when I wrote this thread in an effort to explain why, coming from a mechanism of action perspective, #hydroxychloroquine (#HCQ) for #COVID-19 should be administered with #zinc?
2/ Well, this NYU preprint explains how the team performed a retrospective observational study to compare #hospital outcomes among patients who received #HCQ + azithromycin + #zinc vs. HCQ + azithromycin alone for COVID-19: medrxiv.org/content/10.110…
3/ They found that addition of #zinc sulfate to the #drug combo increased the frequency of patients being discharged home, and decreased the need for #ventilation, admission to the #ICU, and mortality or transfer to hospice for patients who were never admitted to the ICU.
Read 7 tweets
THREAD:
Are you a journalist writing about the newest study by Didier Raoult on #hydroxychloroquine in #COVID19?

Allow me to point to a few issues...

TL;DR: One of the worst studies I have ever read. It provides zero evidence of clinical relevance!

sciencedirect.com/science/articl…
There are MANY issues that would individually make this useless. Considering them all, the paper is borderline nonsensical. We’re talking very fundamental flaws. As pointed out by others, they violate core principles that we have previously outlined.

Note that this study is OBSERVATIONAL. There is no randomization of patients. Such studies can be useful if, and only if, the study question lends itself to an observational design and if the study is performed correctly. Neither of these two criteria are met in this case.
Read 11 tweets
THREAD: A story only one of the world’s biggest newswires could write. @Reuters reporters in 10 countries spoke to 30 doctors about lessons learned through 6 months of the global #coronavirus pandemic. It was fun to be a part of. Here’s what they said: reut.rs/3g1Z4Xc 1/8
@Reuters Earlier this year, doctors were “in a fog,” and #COVID19 treatment guidelines were changing daily. Now, they have a clearer grasp of once-mysterious side-effects like kidney failure and blood clotting. 2/8
@Reuters Surprising progress has been made by simply positioning patients on their stomachs (“proning”) instead of their backs. Widespread testing has had outsized benefits, including for things you wouldn’t think of, like conserving PPE. 3/8
Read 8 tweets
1. This thread 🧵 is about a month overdue.
#COVID19 👉🏻Death Rates 👉🏻Lockdown 👉🏻Economic Crash 👉🏻Masked Silencing 👉🏻Flu Agenda 💉👉🏻& The Giant Gates Web 👉🏻 #Wormwood 👉🏻 [They] knew.
2. 1st part of this🧵I disclose that info is via @delbigtree’s @HighWireTalk video on YT Here 👉🏻 approx 43+ min. Watch it all!
For purpose of record, archiving & to spread, & d/t rampant censorship I am paraphrasing.
AND ADDING ADDITIONAL RESEARCH.
3. As of May 2020 “CDC now says #COVID19 has a death rate of .4% among those that show sysmptons & are infected. If we add the asymptomatic which they are giving very conservatively low at 35% then we come up w/ .26%” They started out telling us it would be 3 to 7% 👉🏻 It’s .4% 👈🏻
Read 26 tweets
🔥Thread hydroxychloroquine #HCQ #COVID19

Pourquoi la très grande majorité des médecins s’accordent aujourd’hui pour dire que l'#HCQ ne marche pas ?

Parce que de très nombreuses études montrent son inefficacité et qu'aucune étude de qualité ne montre son efficacité.
👇1/n ImageImage
Tout en haut de la pyramide de valeur des études, il y a les essais randomisés de grande ampleur. Il y en a désormais 3 sur l’#HCQ dans #COVID19 dont 1 publié (@NEJM) et 2 partagés via communiqué presse (@MartinLandray @ScienceMagazine). On y ajoute 2 méta-analyses solides.

2/n ImageImage
1er essai : @boulware_dr et collègues

#HCQ en prophylaxie (en prévention de l'infection après exposition à risque) chez 821 patients : autant de patients contaminés par COVID-19 avec #HCQ que #placebo. Effets indésirables plus importants avec #HCQ (40% #HCQ vs 17% #Placebo)

3/n Image
Read 25 tweets
There will be a second wave of COVID19 because they are telling you there will be a second wave of COVID19. You can bet on it and you can plan on it. And when they say it occurs do not expect any proof of such. You will just have to believe them. That simple.
@realDonaldTrump will be blamed for the #COVID19 second wave rollout and the #MSM #fakenews #ferrets will repeat the scripted information without so much as a question. The trope will be repeated without surcease that will blame President Trump for this manufactured resurgence.
Remember the #hydroxychloroquine debate. #FakeNewsMedia ferrets were told precisely what to say and they followed the rules perfectly. They never questioned anything about why all of a sudden they were so interested in the medication. But they proved their worth as [DS] slaves.
Read 5 tweets
THREAD: A couple days ago, the WHO stopped #hydroxychloroquine as a treatment for COVID, citing data that it is not effective.

The last time the WHO halted its HCQ trials (May 25), it was prompted by extensive data from a mysterious healthcare analytics firm: SURGISPHERE.
On its website, Surgisphere touted relationships with hundreds of research facilities like University of Minnesota, Stanford, University of Utah & Glasgow, who have all denied such relationships.

(This week the Surgisphere website disappeared.)
Surisphere’s patient data, on which the WHO based its decision, supposedly included the largest health systems on Earth - a big project indeed.

But as @JamesTodaroMD noted last month, Surgisphere's LinkedIn page showed just five employees. Today, that number is one.
Read 7 tweets
En version française, voici les résultats de notre méta-analyse sur l'#hydroxychloroquine avec/sans azithromycine et le risque de mortalité lié au COVID-19. Une méta-analyse permet de combiner le résultat de plusieurs études, on parle de "pooler"

medrxiv.org/content/10.110…
Pooler permet d'augmenter la fameuse puissance statistique. Cette analyse inclut 16 études avec groupe comparatif, soit 15,081 patients (8,072 patients dans le groupe HCQ seule et 7,009 patients dans le groupe soin standards avec respectivement 1 578 décès et 1 423 décès)
RESULTATS : il n'y avait pas d'association entre la prise d'hydroxychloroquine seule et la survie au COVID-19 chez les patients hospitalisés comme le Risque Relatif global est de 0,82 [0,62-1,07] avec une forte hétérogénéité à 82%

Même résultats pour l'HCQ avec azithromycine
Read 9 tweets
Latest data from SMS hospital, #Jaipur stated #HydroxyChloroquine was given in ~4300 healthcare workers as prophylaxis. Only 45 contracted #COVID19 and got recovered later. #Hydroxychloroquineworks
health.economictimes.indiatimes.com/news/diagnosti…
SMS hospital #Jaipur has been declared non-COVID hospital on June 1. Before that the hospital has emerged as a role model for #Rajasthan in managing #COVID19.
Continuous attack is going on to discredit the drug since the beginning. So much thankful to our real Physicians who did not lose hope on #hydroxychloriquine an it's efficacy as a prophylaxis. @MsAnaMcCarthy largest data from India on HCQ prophylaxis is out. Take a look.
Read 6 tweets
❌ Our meta-analysis including 15,081 patients (16 studies) does NOT support the use of hydroxychloroquine with or without azithromycin to reduce COVID-19 mortality in hospitalized patients

➡️ medrxiv.org/content/10.110…

#Hydroxychloroquine #COVID19 #Hydroxychloroquineworks
Hydroxychloroquine was not significantly associated with mortality risk (RR=0.82 [0.62-1.07], I²=82, Pheterogeneity<0.01, n=15)) within hospitalized patients, nor in association with azithromycin (RR=1.33 (95% CI: 0.92-1.92, n=6))
nor in the numerous subgroup analysis by study design, median age population, published studies (vs unpublished articles), level of bias risk
Read 9 tweets
15/06 > #Coronavirus : le #LancetGate révèle des failles de l’édition scientifique bit.ly/2YPpp3J via @lemondefr #LaMethSci
.@PierreCorvol > #LancetGate : il s'agit d'une étude rétrospective à partir de données massives en fait. On a des données issues d'hôpitaux dont on a aucune indication sur l’acceptation des malades sur l'utilisation de ses données et c'est intolérable #LaMethSci
3/06 > #Chloroquine : la revue #TheLancet met en doute le sérieux de l'étude qu'elle a publiée bit.ly/3frImAe via @franceinfo #LaMethSci
Read 21 tweets
@CMOH_Alberta Can you please comment on this Undercover Nurse Video tomorrow at your press #COVID19AB conference...

I have transmitted this video very publicly, so no plausible deniability here.



Sincerely #AlbertansStandTogether #Alberta #Canada #Cdnpoli #coronavirus
@CMOH_Alberta Then I was also wondering why we are'nt exploring the mystery of the use of a completely remarkable off-the-shelf Therapeutic like #Hydroxychloroquine, especially when the FDA has retracted the false narrative that its a killer drug! And POTUS took it!
msnbc.com/andrea-mitchel…
@CMOH_Alberta Yes @Crackedlens and @CMOH_Alberta

CC: @jkenney MUST SEE Thread here!

You have not been forthright with this information and its implications.
Why do we need to lockdown with a powerful therapeutic readily available?

@POTUS took it! He has good Drs!
aapsonline.org/aaps-news-june…
Read 5 tweets
🔥Voilà un thread afin de ne pas avoir à répéter tout le temps la même chose sur la recherche médicale thérapeutique pendant #COVID19 #SARS_CoV_2 #pandemic

👇👇
1/ Les infectiologues cliniciens n'attendaient pas de ttt antiviral permettant une amélioration "spectaculaire" pr une maladie aiguë virale sévère (cf dengue, zika, chik, grippe), il était donc nécessaire d’évaluer rigoureusement et d’espérer un ttt un peu efficace et non toxique
2/ Il existe de nombreux candidats repositionnés qui ont été utilisés et testés et ce dès le début de la pandémie : #lopinavir/#ritonavir, #remdesivir, #hydroxychloroquine, #interferon ß pour n’en citer que quelques-uns
Read 35 tweets
Tabulated the topline results released by the #recoverytrial team on #hydroxychloroquine & #dexamethasone, and went over their protocol (recoverytrial.net/results) to better digest them.

Basic stuff:
- hospitalized patients @ 175 NHS centres
- open label, 5 initial arms
- thread—
Important point from #RECOVERYTrial protocol

- if a patient had a #contraindication to one of the intervention arms, according to the clinical care team at the site, that particular arm was not available to that patient at the time of #randomization
So if a patient enrolled in #recoverytrial had a contraindication to #dexamethasone, that patient was not allowed to be randomized to that arm. So the results need to be interpreted in the context of no contraindication to steroids: already on steroids, #immunosuppression, etc.
Read 11 tweets
Yes, #Hydroxychloroquine is the game changer against COVID-19!

On March 19, Trump "touted" it.

Doctors around the world started using it immediately.

Two weeks later, the global (outside of the US) COVID-19 mortality reached a plateau. Ten days later, it started to decline Image
In the US, seditious Democrat-Socialist governors (New York, Michigan, etc.) impeded access to Hydroxychloroquine, causing tens of thousands of deaths.

In late April, a few countries (UK, Canada, Sweden etc.) reduced or stopped the use of HCQ. They had higher #COVID19 mortality
Social distancing measures and the March lockdowns did play their role in the achieving mortality plateau and reversal, but Hydroxychloroquine was more important.
Read 6 tweets
WOW!!! 😮
#Breaking #BreakingNews
Members of Parliament of #Brazil break into hospital that claimed to have 5,000 infected & 200 deaths from #COVID19 & CAUGHT THEM RED HANDED NOT ONE PERSON, they have FRAUDED THE WORLD!! #Italy #Spain #ArrestBillGates
Brazilians Translated:
5 Members of #Brazil parliament went to hospitals under encouragement by #Bolsonaro to break into hospitals & check to see the number of patients there. This hospital late to be finished but claiming 5000 ppl with COVID19 and 200 dead, so need this hospital
2/
Officials broke in to check it & found the hospital is an absolute mess, not finished, and no patients. The governor is frauding the state and nation and taxpayers & LYING about the numbers to pad the numbers. Embezzlement scheme & to help bring down the country &push #vaccine
Read 48 tweets

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