Discover and read the best of Twitter Threads about #hydroxyurea
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How many patients are on disease modifying treatments for #SCD - data from 2014-2021 presented by Dr. Terri Newman. @ash22 1/n
We're talking about #Hydroxyurea and in 2017, expanded use of #HU as well as L-glutamine and then in 2019 #voxelotor and #crizanlizumab. #ASH22 2/n
They looked at 5022 patients with Rx of DMTs. Those on DMTs were surprisingly mostly in the 18-45 group (the box is wrong on the screenshot) and mostly male and had more VOCs. #ASH22 3/n 
Alright, should we do this? I'm going to attempt my first mini-#tweetatorial on this little capsule right here...
#hydroxyurea is currently the mainstay of disease modifying therapy in #sicklecell disease and with the new landscape of therapeutics, I think we should dive in /1
#hydroxyurea is currently the mainstay of disease modifying therapy in #sicklecell disease and with the new landscape of therapeutics, I think we should dive in /1
It was a century before its first clinical use in cancer that hydroxyurea was created by Drs. Dresler and Stein in Germany. The first approval for clinical use came in 1967 from the @US_FDA for oncological indications. /2
And then in 1984, two key papers in @NEJM and @jclinicalinvest by Letvin et al and Platt et al - FETAL HEMOGLOBIN production! And this of course was the 🔑 that unlocked the potential of HU in SCD. This was the game changer. /3
