Discover and read the best of Twitter Threads about #hyperinsulinaemia

Most recents (2)

Patients with T2DM, CVD, conditions of hyperinsulinaemia, have lower: bone remodelling and osteocalcin levels, and increased rates of fragility fractures.

T2DM “hyperinsulinaemia-osteofragilitas” bone phenotype presents with normal to increased BMD mdpi.com/2227-9059/9/9/…
Hyperinsulinaemia and IR positively associate with increased BMD and fragility fractures

Hyperinsulinaemia enforces glucose fuelling, decreasing NAD+-dependent antioxidant activity:

➡️⬆️ ROS & mt fission,
➡️⬇️ OxPhos ATP production capacity, needed for osteoblasto/cytogenesis.
Osteocytes directly mineralise and resorb bone, & inhibit mineralisation of their lacunocanalicular space via pyrophosphate.

Hyperinsulinaemia decreases vitamin D availability via adipocyte sequestration, reducing dendrite connectivity, and compromising osteocyte viability.
Read 7 tweets
The world’s most powerful tools against respiratory infections is good health, individual health and population health. Both metabolic and mental.

dx.doi.org/10.1136/openhr…

#hyperinsulinaemia
#covid
#vitD
#metabolichealth
#immunity openheart.bmj.com/content/7/2/e0…
“heightened fears that the coronavirus is quickly finding ways to elude the world’s most powerful tools (vaccines) to contain it.”

latimes.com/science/story/…
What we have heard loudest from Government, mainstream media and med/scientists with vested interests, is we must: “socially distance, lockdown to slow/lower spread rate, protect the health care systems, wait for vaccines before life has any hope of returning back to normal”.
Read 22 tweets

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