Discover and read the best of Twitter Threads about #hyperinsulinaemia

Most recents (2)

Patients with T2DM, CVD, conditions of hyperinsulinaemia, have lower: bone remodelling and osteocalcin levels, and increased rates of fragility fractures.

T2DM “hyperinsulinaemia-osteofragilitas” bone phenotype presents with normal to increased BMD…
Hyperinsulinaemia and IR positively associate with increased BMD and fragility fractures

Hyperinsulinaemia enforces glucose fuelling, decreasing NAD+-dependent antioxidant activity:

➡️⬆️ ROS & mt fission,
➡️⬇️ OxPhos ATP production capacity, needed for osteoblasto/cytogenesis.
Osteocytes directly mineralise and resorb bone, & inhibit mineralisation of their lacunocanalicular space via pyrophosphate.

Hyperinsulinaemia decreases vitamin D availability via adipocyte sequestration, reducing dendrite connectivity, and compromising osteocyte viability.
Read 7 tweets
The world’s most powerful tools against respiratory infections is good health, individual health and population health. Both metabolic and mental.…

“heightened fears that the coronavirus is quickly finding ways to elude the world’s most powerful tools (vaccines) to contain it.”…
What we have heard loudest from Government, mainstream media and med/scientists with vested interests, is we must: “socially distance, lockdown to slow/lower spread rate, protect the health care systems, wait for vaccines before life has any hope of returning back to normal”.
Read 22 tweets

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