Discover and read the best of Twitter Threads about #iNTS

Most recents (3)

Here it is!

#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157

It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology Inktober2020 E. coli O157 c...
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?

It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…

#sciart #microbiology Image
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.

Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.

More info at mrsaactionuk.net/MRSA.html #sciart #microbiology Methicillin resistant staph...
Read 34 tweets
1/
See our new @plospathogens paper with the Hinton Lab @jay_salsa on the role of the MacAB-TolC efflux pump during infection by invasive #Salmonella isolates from Africa. doi.org/10.1371/journa…
2/
Whole genome analysis of all sequenced African #iNTS isolates by @yan_salsa @NWenner and @implosian identified several variants of MacAB associated with each lineage.
3/
We showed these MacAB variants change resistance to the antimicrobial peptide C18G and alter #Salmonella replication in macrophages.
Read 5 tweets
1/5
African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by @DrRobKingsley in 2009, inc ybjZ.

But what is function?

In collab with Jared Honeycutt @monack_lab, we've discovered that MacB (YbjZ) influences pathogenesis of ST313

journals.plos.org/plospathogens/…
2/5
Genomes of 285 S. Typhimurium isolates revealed lineage-specific SNPs = macA & macB are pseudogenes

Suggesting that MacAB-TolC efflux pump is functional in S. Typhimurium ST19, but defective in ST313 Lineages 1 & 2
3/5
Beautiful expts designed by Jared Honeycutt & @monack_lab show MacA variant & truncated MacB protein made ST19 sensitive to C18G antimicrobial peptide

& the ST313 macAB SNPs reduced intra-macrophage replication & fitness in murine GI tract

See @monack_lab tweet for details
Read 6 tweets

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