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The largest trial of #ivermectin in early #COVID is now published @NEJM & the results are *NEGATIVE*
#TOGETHER randomized n=1358 outpatients with COVID in 🇧🇷 to IVM vs placebo. No difference in hospitalizations, mechanical ventilation, or death.
nejm.org/doi/full/10.10…
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#TOGETHER randomized n=1358 outpatients with COVID in 🇧🇷 to IVM vs placebo. No difference in hospitalizations, mechanical ventilation, or death.
nejm.org/doi/full/10.10…
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I’ve written about the #TOGETHER trial before (see my fluvoxamine 🧵below)
Briefly #TOGETHER is a large double blind multi-arm platform RCT. Pretty much the 1st 🥇 gold standard for high quality medical research.
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Briefly #TOGETHER is a large double blind multi-arm platform RCT. Pretty much the 1st 🥇 gold standard for high quality medical research.
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TOGETHER enrolled high risk people with COVID from 12 outpatient clinics in Brazil.
Patients could be enrolled up to 7 days after symptom onset (more on this later).
They were randomized to either placebo or to ivermectin 0.4mg/kg daily for 3 days. (Also more on dose later)
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Patients could be enrolled up to 7 days after symptom onset (more on this later).
They were randomized to either placebo or to ivermectin 0.4mg/kg daily for 3 days. (Also more on dose later)
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🚨Results of the #ITECH RCT in Malaysia 🇲🇾 are in & it’s yet another NEGATIVE result for ivermectin:
-n=500 high risk outpatients w/COVID randomized to 0.4 mg/kg IVM x5 days vs SOC
-no difference in rate of progression or time to recovery
-3x more adverse events w/ ivermectin
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-n=500 high risk outpatients w/COVID randomized to 0.4 mg/kg IVM x5 days vs SOC
-no difference in rate of progression or time to recovery
-3x more adverse events w/ ivermectin
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I-TECH was an open label RCT of IVM (0.4 mg/kgx5 days) vs standard of care (SOC)
It enrolled high risk outpatients (>50 yo w/ ≥ 1 comorbidity) w/in 7 days of COVID symptoms
In summary, HIGH risk pts given HIGH dose IVM EARLY & adequately powered 🤔
clinicaltrials.gov/ct2/show/NCT04…
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It enrolled high risk outpatients (>50 yo w/ ≥ 1 comorbidity) w/in 7 days of COVID symptoms
In summary, HIGH risk pts given HIGH dose IVM EARLY & adequately powered 🤔
clinicaltrials.gov/ct2/show/NCT04…
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We don’t have the full results yet but based on the 🇲🇾 Ministry of Health data this was a NEGATIVE trial.
- IVM recipients did numerically worse: 21.2% progressed to severe disease vs 17.9% receiving SOC (OR 1.29 CI 0.8-2.0)
- time to progression was similar: 2.9 vs 3 days
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- IVM recipients did numerically worse: 21.2% progressed to severe disease vs 17.9% receiving SOC (OR 1.29 CI 0.8-2.0)
- time to progression was similar: 2.9 vs 3 days
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#iTech | ¿Les ha pasado alguna vez que tienen una lista grande de archivos en una carpeta y necesitan pasar los nombres de los archivos a Excel?
#iTech | Vamos a explicarles como extraer todos los nombres de los archivos que se encuentran en una carpeta para que puedan pasarla a Excel.
#iTech | Aclaro que hay muchas maneras de hacerlo, pero les mostraré la mas práctica.
