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1) Welcome to a new #accredited #tweetorial on #Bronchiectasis (#NCFB or #bronchiectasis) & its management, by Christina Thornton MD (@Cthornton32), respirologist & clinician scientist in Calgary 🇨🇦. Follow along and earn 0.75h CE/#CME #physicians #nurses #NPs #PAs #pharmacists! 
2) I am very excited to be among the founding faculty in this initiative! FOLLOW US for awesome expert-led education #pulmtwitter!
👍@BronchiectasisR @COPDFoundation @EMBARCnetwork @ELF @profJDchalmers @sunjayMD @DrHollyKeir @becleartoday @ephesians_1_7 @NTMinfo @AlibertiStefano
👍@BronchiectasisR @COPDFoundation @EMBARCnetwork @ELF @profJDchalmers @sunjayMD @DrHollyKeir @becleartoday @ephesians_1_7 @NTMinfo @AlibertiStefano
3) This program is supported by an educational grant from Insmed & is intended for healthcare professionals. Statement of accreditation and faculty disclosures at pulmonarymed-ce.com/disclosures/. CE/#CME credit from @academiccme.
#Tether - Let's take a look at the team that created USDT and their strange connections - #illegal ones. 🧐
➡️ NYAG INVESTIGATION
➡️ Origin, core-team and shady connections/frauds
This is a continuation of the last thread, which you can find below ⬇️
THREAD 🧵🐋
➡️ NYAG INVESTIGATION
➡️ Origin, core-team and shady connections/frauds
This is a continuation of the last thread, which you can find below ⬇️
THREAD 🧵🐋
[2/x] CHAPTER ONE - #NYAG INVESTIGATION - In the Bitfinex and Tether fraud case
Tether claimed at the outset that it would cooperate with the NYAG, after which it obstructed the handing over of relevant documents and prolonged the process.
Tether claimed at the outset that it would cooperate with the NYAG, after which it obstructed the handing over of relevant documents and prolonged the process.
Wie hängen eigentlich
#LongCovid
#PostCovid
#EBV
#MCAS und
#MECFS
zusammen?
Oder warum #MCAS ein gemeinsamer Nenner sein könnte:
🧵
#LongCovid
#PostCovid
#EBV
#MCAS und
#MECFS
zusammen?
Oder warum #MCAS ein gemeinsamer Nenner sein könnte:
🧵
1. #PostCovid & insbesondere #LongCovid sind an sich keine Krankheiten, sondern rein beschreibende Begrifflichkeiten.
Das zu verstehen ist elementar, für alle weiteren Überlegungen, fürs Verständnis & wichtige (therapeutische) Entscheidungen.
#pwMECFS könnten davon profitieren
Das zu verstehen ist elementar, für alle weiteren Überlegungen, fürs Verständnis & wichtige (therapeutische) Entscheidungen.
#pwMECFS könnten davon profitieren
2. Post (nach) Covid und Long (langes) Covid beschreibt also erstmal „nur“, dass Beschwerden „nach“ einer Covid-Infektion auftraten, bzw. „lange“ anhalten. Es sagt nichts über die Krankheit, die dahinter steckt und deren Pathophysiologie aus.
Die #Mastzelle
➡️ Von der Medizin völlig unterschätzt und kaum beachtet.
Dabei kämpft sie direkt an der Front, in der allerersten Reihe und mit unzähligen Waffen.
🤜🏻🦠
Sie ist eine #Immunheldin - bei #MCAS leider etwas außer Rand & Band.
🧵
➡️ Von der Medizin völlig unterschätzt und kaum beachtet.
Dabei kämpft sie direkt an der Front, in der allerersten Reihe und mit unzähligen Waffen.
🤜🏻🦠
Sie ist eine #Immunheldin - bei #MCAS leider etwas außer Rand & Band.
🧵
Das entspricht (ungefähr) dem med. Standardwissen über sie:
„Eine Mastzelle ist eine zu den Leukozyten gehörende Blutzelle. Sie reift aus hämatopoetischen Stammzellen im Knochenmark heran… Sie wird IgE-vermittelt aktiviert (Allergien)…“
flexikon-mobile.doccheck.com/de/Mastzelle
„Eine Mastzelle ist eine zu den Leukozyten gehörende Blutzelle. Sie reift aus hämatopoetischen Stammzellen im Knochenmark heran… Sie wird IgE-vermittelt aktiviert (Allergien)…“
flexikon-mobile.doccheck.com/de/Mastzelle
Das ist, was sie eigentlich kann und macht. Denn getriggert wird sie längst nicht nur durch #IgE und sie sezerniert weit mehr als nur #Histamin.
Quelle: ruhtenberg.info/mcas/
Quelle: ruhtenberg.info/mcas/
1/ All B cells have the immunoglobulins IgM and IgD on their cell surface. The DNA contains both the information to create these two classes of immunoglobulins. They will be produced in equal amounts during the B cell development.
2/ Once a B cell is activated toward a pathogen, it will begin to secret immunoglobulins (antibodies) in the form of the IgM. This is the only thing it is able to create and secret at this point.
Hey #MedTwitter!!
This morning at our VA we had Chief @photon_ick give us a case of #ChronicSOB, where it turned out that the patient had #ABPA (#allergic bronchopulmonary #aspergillosis). It's a diagnosis we don't see too often, but one you'll definitely encounter here!! 🗝️👇
This morning at our VA we had Chief @photon_ick give us a case of #ChronicSOB, where it turned out that the patient had #ABPA (#allergic bronchopulmonary #aspergillosis). It's a diagnosis we don't see too often, but one you'll definitely encounter here!! 🗝️👇
This is an #allergic condition, with 2 main predisposing conditions: #asthma & #cysticfibrosis
It can be more rarely seen in other lung disease/immunodeficiencies, but without the right lung environment like this, it is almost NEVER seen!!
It can be more rarely seen in other lung disease/immunodeficiencies, but without the right lung environment like this, it is almost NEVER seen!!
Very happy (and relieved) that our work on a beneficial function of the #AllergyModule of the #ImmuneSystem (#IgE antibodies and #MastCells) in host defense against #bacteria is out: cell.com/immunity/fullt…
Please check out the paper or the thread below if you want to know more
Please check out the paper or the thread below if you want to know more
2/11 First things first: Many thanks to the amazing people and friends involved in this study over the last 6 years, especially my mentors Steve Galli @stanford and @sylviaknapplab as well as all co-authors (on twitter: @lauren_popov, @S_Zahalka, @maryemradhouani, @immceptionl)..
3/11 ...and host institutions @cemm_news, @meduni_wien and @stanfordmed; special thanks to @bobby_network for the superfancy 3D artwork!
Our paper on the emergence of genomic diversity and recurrent mutations in #SARSCoV2 is now out in #IGE tinyurl.com/yb4mxhes As with many others, we’ve been working hard tracing the evolution of #SARSCoV2 using thousands of genomes 🧬shared on @GISAID. Here's what we found👇/1
Here we analyse >7500 viral genomes from all around the 🗺️ We show that the time of the host-jump of #SARSCoV2 into humans dates to late last year, consistent with estimates by several others
Genetic data shows #SARSCoV2 only recently started infecting us & was detected fast. /2
Genetic data shows #SARSCoV2 only recently started infecting us & was detected fast. /2
Around the world we see large amounts of regional genetic diversity with marked & repeated intros to many countries
Eg. we place genomes sampled from UK patients throughout the global tree. There is no such concept as a patient zero (see @nextstrain also for visualisations) /3
Eg. we place genomes sampled from UK patients throughout the global tree. There is no such concept as a patient zero (see @nextstrain also for visualisations) /3
a removal of a subset of #Tregs called T follicular regulatory cells (Tfr) from the immune system in #Foxp3-cre Bcl6-fl/fl mice #paradoxically reduces, rather than increases, #peanut-specific #IgE responses.
#immunology
bit.ly/2RAMe8L
#immunology
bit.ly/2RAMe8L
And if you think maybe their knockout mice are some kind of weirdos, not really. Their model also shows that total IgE is increasing as expected. So, the system the authors are using is within acceptable norms.
bit.ly/2RAMe8L
bit.ly/2RAMe8L
The authors then went on to show that IL-10 derived from Tfr cells are important for promoting peanut allergy-producing IgE production. (IL-10 is lesser understood cytokine but it is generally accepted as an immunosuppressant.) #immunology
