Discover and read the best of Twitter Threads about #ijaa

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🔥With @DgCostagliola we have published a response to the article by Risch in @AmJEpi on the outpatient treatment of #COVIDー19

There was and is no convincing evidence that #HCQ + #Azithromycin prevent hospitalisation in high-risk #COVID19 outpatients👇

academic.oup.com/aje/article/do…
In Gautret 1, that should be retracted by #IJAA, 6 patients were excluded w/o justification among the 26 treated with #HCQ. The appropriate test should compare the 14 patients who received #HCQ alone to the 6 who received the combination, and this test is not significant (p=0.39)
Risch stated that the only valid criticism against this trial is the lack of randomization. He rejects the criticism about the "small study size", saying that size matters only when no evidence is found. But no evidence is found in this study as shown above...
Read 13 tweets
Review #IJAA article 1 @IHU_Marseille

sciencedirect.com/science/articl…

"manuscrit non informatif présentant de graves lacunes méthodologiques. Les résultats ne justifient pas les conclusions sur l'efficacité #HCQ ds #Covid19 et de l'avis de l'examinateur ne justifient aucune conclusion" ImageImageImageImage
C'est caustique :
"Il est remarquable que ds un essai randomisé, lorsque seul le hasard a pu introduire des différences entre les groupes les auteurs se mettent en 4 pr présenter longue liste de caractéristiques de base afin de bien documenter la comparaison entre les groupes
Alors qu'ici, dans une comparaison non randomisée de patients de différents centres qui diffèrent clairement, les auteurs n'ont pas fait le moindre effort pour présenter ces caractéristiques de base."
😮😮
Read 3 tweets

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