Discover and read the best of Twitter Threads about #immunodeficiency

Most recents (9)

INTRAVENOUS IMMUNOGLOBULIN

Or IVIG as the 😎 cool kids call it

⭐️ What is it?

⭐️How did we first start using it?

⭐️How was it accidentally found to treat autoimmune conditions?

A thread 🧵

#meded #rheumtwitter @HRheuminations #immunodeficiency
Immunoglobulin is another way of saying antibodies (Abs)

Abs are what your immune system produces after being exposed to an infection or what you produce in response to a vaccine to protect you long term
IVIG is “pooled” antibodies (Ab)

Originally made to treat people who can’t make Ab

(More on this soon)

⭐️ Why pooled?

If you took Ab from just me, then you would be immune to just what I’m immune to

If you take antibodies from 1000s of people, you’re immune to much more
Read 13 tweets
Thread 🧵👇:
After so many years of work and as a post Epstein-Barr virus infection #MECFS sufferer it makes me really happy that they have put our article on the cover of the August issue of Pathogens journal 👉:mdpi.com/2076-0817/11/8
(1/)
Until recently nobody talked about post-viral syndromes (actually they should be called chronic infectious syndromes) and they left all of us patients isolated both at a health and social level. Unfortunately it took another virus like #SARSCoV2 to show us how viruses are ...(2/)
...capable of developing chronic diseases like #LongCovid . It is curious that for bacterial infections we use antibiotics but for viral infections we leave it to our immune system to manage to control it. This must change. (3/)
Read 15 tweets


'Endemic Delusion' in Denmark - coming to a continent / country / city / town / village / house near you, if it isn't already in your living-room.



#FarFromNormal
#P100
#ElastomericBulletproof ImageImageImageImage


Q & A.

Not sure why anyone would focus on one particular continent when this happens to be a global pandemic.

When Pi?

#ButtonUp #N95 #FFP3 #GoElastomeric #P100 ImageImageImageImage
Read 272 tweets
EU regulator #EMA authorises #Pfizer’s COVID vaccine for #kids 5-11 | Nov 25
- the studies done on Pfizer’s vaccine in children haven’t been big enough to detect any rare side effects from the second dose, like the chest and heart #inflammation
financialexpress.com/lifestyle/heal…
#UK #Vaccine #FatalityRate Higher than Virus, Official Lies, Money Corrupts Medicine | Aug 13
- Of those who contracted COVID from the vaccine the fatality rate was over 6%.
- But the overall fatality rate in the UK is only 2.2%.
globalresearch.ca/uk-vaccine-fat…
Read 10 tweets
We have an exciting new #preprint on @medrxivpreprint ! A novel class of #primaryimmunodeficiency, with the discovery of ITPR3 mutations in two families with combined immunodeficiency. As always, studying #PID teaches us so much about biology! 1/8

medrxiv.org/content/10.110…
The work is based on patients identified @UZLeuven by Rik Schrijvers and @IsabelleMeyts. Both patients had a combined #immunodeficiency with sensitivity to infections, one complicated by peripheral #neuropathy and one by #autoimmune hemolytic anemia. Over to the gene hunters! 2/8
Mutations in ITPR3 were identified by Erika Van Nieuwenhove and Frederik Staels. ITPR3 is part of a #Calcium channel, so we turned to the Serysheva lab @Irina52948708 to predict the impact on structure. Clear as day, the mutations change the charge of the channel. 3/8
Read 8 tweets
19M +fever/cough x 2wks. Exam: n/l except draining fluctuance on chest. CT: lung abscess adjacent to skin. Cx: Aspergillus nidulans. 6mos ago skin abscesses 2/2 Burkholderia. 1yr ago, pneumonia 2/2 Serratia. HIV(-). CBC nl. Test for most likely underlying immunodeficiency?
1/8) Answer: dihydrorhodamine test. Case of chronic granulomatous disease (CGD), one of the primary immunodeficiencies that can sometimes present in adulthood similar to common variable immunodeficiency (CVID), GATA 2 deficiency, hyper IgE syndrome (Job syndrome). #IDMedEd
2/8) GATA 2 deficiency was previously quizzed. Check it out again: . #IDMedEd #immunodeficiency Image
Read 9 tweets
Important 👉 Gut #microbiome dysbiosis can be a downstream response to intracellular infection in blood + tissue☝️Eg: Here, HIV lowered CD4 T cell count (host immunity), which then promoted both bacterial + viral gut dysbiosis in the same patient: ncbi.nlm.nih.gov/pmc/articles/P… ImageImage
From study👉 “Together, these studies indicate that severe #immunodeficiency is likely the mechanism leading to changes in the fecal #microbiome, including bacteria and viruses, and that immune reconstitution, such as through early ART, may restore the healthy enteric microbiome”
The trend has led me to propose that, in some chronic inflammatory conditions 👉 gut #microbiome imbalance (dysbiosis) may serve as a predictive marker of increasing systemic #immune dysfunction☝️More background in this article I wrote: microbeminded.com/2017/11/06/gut… ImageImageImage
Read 3 tweets

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