Discover and read the best of Twitter Threads about #inflammation

Most recents (24)

1/ 🧵 What’s in a name? ‘Long Covid’ ‘post-acute Covid syndrome’. What does that make you think of? Tiredness? #longcovid is covid related THROMBOTIC VASCULITIS. Sounds serious, right? ✅ 🤷🏻‍♀️
2/ thrombotic vasculitis is when the spike protein makes your blood vessels inflamed and form little clots that block small blood vessels 🩸 #MicroClots I like evidence so here you go portlandpress.com/bioscirep/arti…
3/ when your blood has little clots in it filled with amyloid it causes more Inflammation. Think of when you get a cut and the skin goes red and sore. That’s inflammation. Imagine that in your blood vessels. The oxygen in your blood then struggles to get to all the tissues. 🩸 🤒
Read 15 tweets
1) How I cured my #LongCovid in 3mos after suffering for almost a year. This was my last hope. I researched what #Covid does to the body, came up with a list of "clinically studied" supplements and...
2) took them all. Firstly, I am not a MD. In March 2021 I caught Covid while working as a #frontline #healthcare worker. My symptoms of #brainfog, #fatigue, #jointpain, #muscleweakness, morning #stiffness happened after my recovery. At the time, this #postcovid #syndrome was...
3) was just starting to be discussed online. The the term #Longhauler was coined. Those in the #ME, #CFS, #Lyme #MCAS #community starting speaking out about the similarity of #symptoms with #LC. #Covidclinics started to sprout up, include one at the....
Read 48 tweets
😱😱😱War Room and Daily Clout teamed up to report on the Pfizer docs and the data is horrifying 1/🧵⬇️ Image
Pfizer and FDA KNEW BY DEC 2020 the shots waned, there was “vax failure” & “covid” was an effect.

In May 2021 Pfizer knew about the heart damage in kids & FDA rolled out the EUA anyway. Parents weren’t made aware til August.
2/🧵⬇️ Image
Pfizer & FDA KNEW MRNA, spike & nanoparticles didn’t stay at the injection site, instead traveling to the bloodstream & to liver, spleen, adrenals, lymph nodes & ovaries.
3/🧵⬇️ Image
Read 38 tweets
Thread on #Magnesium and why it is fundamental for our #health. #micronutrients
..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.
The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.
Read 19 tweets
Excited to share our new paper out at @NatImmunol today! We discovered the limiting factor for #brain #Tregs is #IL2, and developed a new #genetherapy to treat #traumaticbraininjury and other #neuroinflammatory pathologies. 1/12

nature.com/articles/s4159…
The work started more than 10 years ago, after my brother Russell died following a #traumaticbraininjury. The more I read into it, the more treatable #neuroinflammation seems. Obviously there is a #brain delivery problem, but stopping #inflammation is basic #immunology! 2/12 Image
We had a great post-doc, @EmanuelaPasciu1, drive a project showing #Tcells in mouse and human brain, with key functions. Among these T cells were a small population of anti-inflammatory #Tregs, again in mouse and human. 3/12
cell.com/cell/fulltext/…
Read 12 tweets
"We evolved to be physically active. But most of us avoid physical activity."

The Active Grandparents Hypothesis

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:
"We evolved from #apes and apes are couch potatoes."

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:


#evolution #hominin #anthropology #physiology
"Your average hunter-gatherer walks from New York to LA every year."

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:
Read 24 tweets
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Read 48 tweets
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
Read 93 tweets
While #science thought us that we can even cut and paste #genes with #CRISPR technology…even with that we only influence 3% to 5% of #chronicillness. The rest depends on #how you #live your #life!!! So how do we #SelfRegulate our #body?
1. Good #sleep is more important than most think! What happens during sleep? The fluctuation of consciousness…that we call the waking state. But in many wisdom traditions of the world, the waking state is merely a lucid dream that consciousness is having…
Read 41 tweets
Study from @salkinstitute found that partial reprogramming using the #Yamanaka transcription factors (#Oct4, #Sox2, #Klf4 & #cMyc) for short periods of time:

-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-long-term partial reprogramming led to rejuvenating effects in different tissues, such as the #kidney & #skin, and at the #organismal level; duration of the treatment determined the extent of the beneficial effects.
-The rejuvenating effects were associated with a reversion of the #epigenetic clock and metabolic and #transcriptomic changes, including reduced expression of genes involved in the #inflammation, #senescence & #stressresponse pathways.

nature.com/articles/s4358…
Read 4 tweets
Burning of biomass fuel for cooking and heating purposes results in household #AirPollution (#HAP), which have adverse health impacts. We need strong voices and concerted efforts to take measures for HAP exposure reduction #AirPollutionEquity 1/n
Thread 🧵👇
Highlights and publication links from my own research on #HouseholdAirPollution and #health impacts in India🇮🇳, Nigeria🇳🇬and USA🇺🇸
.@cleancooking .@waqsouthasia .@UofC_CGH .@CPCB .@ISEE_global .@momsforcleanair .@WBPCB #WomenInSTEM #globalhealth #epitwitter #AcademicTwitter 2/n
Increased particulate matter pollution results in ⬆️prevalence of hypertension, platelet hyperactivity, and ⬆️oxidized low-density lipoprotein and anticardiolipin antibody, showing higher risk of cardiovascular diseases among underprivileged women 3/n
onlinelibrary.wiley.com/doi/abs/10.111…
Read 13 tweets
This one aimed to assess whether inflammation mediates the Black-White incident diabetes disparity.
- In this prospective cohort study of Black and White adults, Black adults had higher CRP and higher rates of incident diabetes than White adults.
- Inflammation as measured by CRP was found to be a risk factor for diabetes regardless of race.
Read 7 tweets
This is the most straightforward explanation for chronic symptoms in at least a subset of #LongCovid patients. Partly b/c if the #virus is still present its activity can directly contribute to other phenomena also being documented in LongCovid
2/ Persistence of #SARS-CoV-2 in tissue could lead to shedding of spike protein into blood, which can catalyze the ongoing formation of microclots and hyperactivated platelets
3/ Persistence of SARS-CoV-2 can lead to ongoing downregulation of interferon and/or T cell signaling by the virus, creating an optimal atmosphere for activation of EBV or other #pathogens normally controlled by such immunity
Read 10 tweets
This one suggests that low-grade systemic inflammation promotes proteasome activity through activation of the NF-κB signaling and reduces the insulin-dependent anabolic potential in the aged human skeletal muscle.
Main findings:

Older adults with plasma  hsCRP > 1 mg/L (defined as elevated systemic inflammation; ESI), but otherwise healthy demonstrate:
i) increased proteasome activity, accompanied by increased protein carbonylation and IKKα/β phosphorylation.
Read 21 tweets
EU regulator #EMA authorises #Pfizer’s COVID vaccine for #kids 5-11 | Nov 25
- the studies done on Pfizer’s vaccine in children haven’t been big enough to detect any rare side effects from the second dose, like the chest and heart #inflammation
financialexpress.com/lifestyle/heal…
#UK #Vaccine #FatalityRate Higher than Virus, Official Lies, Money Corrupts Medicine | Aug 13
- Of those who contracted COVID from the vaccine the fatality rate was over 6%.
- But the overall fatality rate in the UK is only 2.2%.
globalresearch.ca/uk-vaccine-fat…
Read 10 tweets
In our recent review on #LongCovid/PASC we bring up the possibility that dysbiosis or imbalance of host #microbiome communities (in ecosytems such as the gut, lungs, or oral cavity) might contribute to at least some LongCovid symptoms: frontiersin.org/articles/10.33…
2/ More specifically immune dysregulation driven by #SARS-CoV-2 might allow pathobionts (bacteria capable of both commensal + virulent acitivty) in the gut, mouth, or other body sites to collectively shift towards a state of imbalance + pro-inflammatory gene/metabolite expression
3/ Conversely, b/c composition + activity of the microbiome can influence host susceptibility and ongoing control of #viral pathogens, exisiting microbiome dysbiosis in a range of body sites may serve as a form of predisposition to LongCovid
Read 11 tweets
@lasleh @yleuutiset #Fimea @THLorg Covid-19 or #GrapheneOxide? Poisonous Nano-Material found in #CovidVaccines and #FaceMasks | JULY 10, 2021
- In Oct 2013 the #EuropeanUnion launched two flagship projects: the Human Brain Project (“HBP”); and, the Graphene Flagship (“GF”)
dailyexpose.co.uk/2021/07/10/the…
@lasleh @yleuutiset @THLorg Official interim report of #Pfizer's vaccination vial analysis explained by La Quinta Columna | JUNE 30, 2021
- Prof. Dr. Pablo Campra #Madrid of the University of #Almeria, @ualmeria Spain
docdroid.net/file/download/… ImageImage
@lasleh @yleuutiset @THLorg @ualmeria #SoyUAL Pablo Campra
Universidad de Almería | UAL · Department of Agronomy
PhD in Chemical Sciences
- Pablo Campra currently works at the Food Technology Division of the Department of Agronomy, University de Almeria (Spain)
researchgate.net/profile/Pablo-…
Read 16 tweets
In a meeting I watched today, microglia priming was mentioned in #LongCovid and #ME/CFS. It’s important to clarify what “microglia priming” means. Microglial priming does not mean that after a trigger has “cleared” microglia remain perpetually activated
2/ Instead, microglia priming goes like this 👉 When microglia or other glial cells detect #infection, injury, or inflammatory mediators, they enter a state of activation in which they change morphology and release their own neuroexcitatory inflammatory mediators
3/ Then, after activating, they retain a “primed” functional state which causes an even more robust response to *subsequent* infectious/immune/#inflammatory challenges. And as cells, microglia live long lives (they are not replaced as often as many other cell types)
Read 13 tweets
#Covid19 is probably the greatest debunker in #medicine we have seen...

Read this ... 👇🏾
🧵 *** The researchers found no evidence of a difference in response in biochemical markers of #inflammation between patients with #MIS-C/PIMS-TS who were treated with #IVIG, #steroids, or #biologics, compared with those who were not.
*** Despite a lack of evidence, 🇬🇧 and 🇺🇸 treatment guidelines for MIS-C/PIMS-TS have become very similar.

*** By the end of the study period, most patients had received immunomodulation.
#AcademicChatter #AcademicTwitter #MedTwitter #foamed #MedStudentTwitter #LongCovidKids
Read 5 tweets
1/17 Happy Saturday, everyone! I‘m Michael Boffa, Assoc Prof of Biochemistry at Western University in London, Canada. @westernuBiochem @SchulichMedDent @WesternU. Thank you to @Lpa_Doc for the kind invitation to be a guest Tweetorial leader – today’s lesson: Lp(a) and thrombosis!
2/17 I have been studying Lp(a) with @MarlysLPA for >20 yrs. There’s never been a more exciting time for Lp(a)! Fun fact about me: I have very high Lp(a) (250 mg/dL) and I’m our lab’s main blood donor. If you see lab studies using purified Lp(a), it is probably mine!
3/17 Word association: heart attack…atherosclerosis (hardening of the arteries). Amirite? 😅 But the direct cause is actually thrombosis: in this case, a blood clot in a coronary artery blocking blood flow to heart muscle.
Read 17 tweets
(1/n) A brief #tweetorial highlighting the key aspects of our recent paper in #Cancer Discovery ⁦@CD_AACR⁩ on how cancers with #Chromosomal_Instability evade immune surveillance prompting #metastasis #ScienceTwitter cancerdiscovery.aacrjournals.org/content/early/…
We’ve previously shown that CIN can drive #metastasis through the generation of chronic #inflammation arising from persistent activation of #cGAS #STING signaling. However it wasn’t clear how cells eschewed the immune stimulating effect of this pathway. nature.com/articles/natur…
To address this, we compared isogenic cells with high vs. low levels of CIN and found that cells with high levels of CIN upregulated #ENPP1 an extracellular enzyme shown by @lingyinli1 and Tim Mitchison to hydrolyze #cGAMP
Read 16 tweets
1/ This excellent study by @aaronmring/@VirusesImmunity and team found that COVID-19 patients exhibit dramatic increases in the production of antibodies against thousands of human extracellular and secreted proteins (the exoproteome) compared to controls 👇
2/ The million dollar question is: what molecular mechanisms underly this antibody/#autoantibody production? It is worth interpreting the findings via the lens of human #microbiome/#virome activity + the activity of persistent pathogens (such as EBV) harbored by study subjects.
3/ Every study subject harbored extensive microbiome/virome communities comprised of trillions of organisms during #COVID-19 infection…with such ecosystems now understood to persist beyond just the gut but also in other body sites (#lung, liver etc).
Read 15 tweets

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