Discover and read the best of Twitter Threads about #intravital

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We found unique breast immune cells in the duct walls – ductal macrophages. They remove dying cells, help remodelling + are key players in cancer.

How did we get from this first sighting to finding their identity and function? Follow this thread!
bit.ly/35o2XSj
1/n Discovery of mammary ductal macrophagesTissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
The breast contains mammary ducts surrounded by fat, blood vessels, immune + other cells.

We use 3D imaging to investigate the complex relationships b/w these cells to better understand disease.
#microscopy #mammarygland
2/n
The ducts form a tree that branches through the breast and blooms and recedes in pregnancy and weaning. These are precancerous mouse ducts, alveoli in lactation and a summary of development in mice.
3/n Precancerous mammary ductsMicroscopic breast alveoli in lactation
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