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One of the problems in biomedicine is that attractive models are sticky, meaning that ppl still refer to them even though the underlying premises have been discredited. In science lingo attractive models = "truthiness." Sound right but they are wrong. Here's an example. /1
Ppl are highly influenced by the idea that sirtuins are central regulators of longevity. Many problems with this concept. 1st, SIR2 is only required for 1 (not both) models of yeast longevity. 2nd, there is NO FITNESS ADVANTAGE to yeast mother cells with long lifespans. /2
This means that it is not plausible that SIR2 was conserved as a longevity gene. 3rd, the mechanism by which SIR2 extends lifespan in yeast is not conserved in other organisms. 4th, SIR2 overexpression in worms, flies & mice doesn't make animals live longer. /3
