Discover and read the best of Twitter Threads about #irbscience

@GenomeMedicine

#IRBScience: Published in @GenomeMedicine, the latest work from the SBNB lab points to the co-occurrence of #cancer driver genes as a key to precision medicine.

Read👓the news➡️bit.ly/2RP3WFf

(1/4) Follow this thread to learn more ↘️
#WorldCancerResearchDay

The system is called Targeted Cancer Therapy for You (TCT4U), and it's aimed at predicting tumour response to different treatments.💊

It has allowed the identification of a set of complex biomarkers🧬that have now been made available to the medical-scientific community.

(2/4)↘️

@ptck72

"The sum of two or more mutated #Cancer driver genes affects the tumour's response to treatments" says @ptck72, "through this work, we see that studying cancer driver genes as a whole can bring about a great advance towards precision medicine".

#WorldCancerResearchDay
(3/4)↘️

@Eduard_puig

Today is #WorldAlzheimersDay 🧠 and this disease has been on #IRBBarcelona's agenda since its start.

@Eduard_puig is one of the committed scientists who recently made an important contribution to the field.
(1/4)

@Eduard_puig

In June, @Eduard_puig, @SoniaCiudad and Natalia Carulla, among others, revealed the specific ensembles of Aβ protein that have the capacity to disrupt the membrane of neurons, causing their death.

➡️bit.ly/3clhW34
#IRBScience #WorldAlzheimersDay
(2/4)

@ShorterLab

In fact, the @ShorterLab, one of the 🔝groups in protein aggregation, published a review on their work in @TrendsNeuro.

➡️cell.com/trends/neurosc…
#WorldAlzheimersDay
(3/4)

@bbglab

#IRBScience: The @bbglab publishes "A compendium of mutational cancer driver genes" in @NatureRevCancer, with mportant implications in clinical decision making.

📢568 genes identified with the potential to trigger #cancer!

➡️bit.ly/2DUxvSn
(1/5) @nlbigas @fran_mj88

The study stands on the analysis of the genomes of 28,000 tumours from 66 types of cancer and it's a major update of the #IntOGen platform (intogen.org), aimed at identifying mutational cancer driver genes.

(2/5)

@nlbigas

“The compendium of driver genes provides cancer researchers, both in the clinical and basic research setting, with crucial knowledge and it has an important impact on clinical decision-making,” says @nlbigas, head of the @bbglab at @IRBBarcelona and @icreacommunity.

(3/5)

Read 5 tweets

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Una anàlisi filogenètica🕎revela l'evolució del transportador mitocondrial de calci↕️
El sistema es va duplicar generant dos sistemes no equivalents fa uns mil milions d'anys, abans que els fongs i els animals divergissin evolutivament.

➡️ bit.ly/2XWvOL2
#IRBScience

@gabaldonlab

2/3
Els models de fongs que s'utilitzen actualment per l'estudi de la regulació mitocondrial del calci no són els adequats, els quítrids serien els únics fongs que posseeixen un sistema similar al nostre.

L'últim treball del @gabaldonlab s'ha publicat a la revista @NatureComms.

@toni_gabaldon

3/3
@toni_gabaldon: "Reconstruint la història evolutiva d'aquestes proteïnes hem pogut resoldre una paradoxa, i trobar els veritables equivalents del sistema humà 🧍 en fongs🍄, el que obre noves vies per usar-los com a models d'experimentació".

Read 3 tweets

@genstability

📢TLK protein inhibition activates the innate #ImmuneSystem, thus becoming a potential therapeutic target for enhancing the effect of some #cancer treatments.

The latest study from @genstability lab is now out in @CellReports.

➡️bit.ly/2PoObDR
#IRBScience
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@genstability

“The activation of innate immunity in cancer has recently become an active area of research as it has become clear that the innate immune response influences chemotherapy and immunotherapy,” comments @genstability, who recently took up a new position at @theNCI.
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@ssurebayona

“This could help us understand our previous observation that TLK depletion caused replication stress and help us exploit the effects of TLK depletion for cancer therapy,” says @ssurebayona, first author of the study, now a postdoc at @TheCrick and #IRBAlumni.
(3/4)

@FranSupek

Les mutacions en el genoma de #càncer:
boira🌫️amb possibilitat de tempesta⛈️

@FranSupek i @davidmasp, del @GenomeDataLab han descobert un mecanisme que genera una #boirademutacions en càncers de pulmó, cap-coll i mama, entre altres.

➡️bit.ly/39Svbqs
#IRBScience
(1/5)

La #boirademutacions té lloc quan la cèl·lula està en un procés de reparació de l'ADN i, alhora, els enzims APOBEC (per fer front als virus) estan actius.

El procés és més actiu en càncers metastàtics en fase avançada: permetent-los resistir als medicaments i radiació.
(2/5)

@FranSupek

"Creiem que aquesta #boirademutacions, impulsada per APOBEC, té un potencial mutagènic que iguala o fins i tot supera el del fum de tabac o la radiació UV", explica @FranSupek, "això fa que APOBEC sigui un objectiu terapèutic molt interessant per combatre el càncer".
(3/5)

Read 5 tweets

@GenomeDataLab

Mutations in #cancer genomes:
foggy with a chance of thunderstorms⛈️

The @GenomeDataLab describes in @NatureGenet the #mutationfog, which causes hundreds of mutations in each tumor, in some cancers such as lung, head-neck and breast.
➡️bit.ly/3hYOPUC
#IRBScience
(1/5)

The 'normal' DNA repair process can become coupled to the APOBEC enzyme–typically used by human cells to defend against viruses and trigger this #mutationfog.

Appears to be more active in late-stage metastatic cancers: helps the cancer evolve and resist drugs/radiation.
(2/5)

@FranSupek

@FranSupek: “We think that this APOBEC-driven #mutationfog has a mutagenic potential that matches or even exceeds that of well-known strong carcinogens, such as tobacco smoke or UV radiation. This finding makes APOBEC an attractive target for treating cancer”
(3/5)

Read 5 tweets

@GenomeDataLab

#IRBScience: Did you know that 7% of #cancer cell lines are misclassified and actually correspond to a different type of cancer?

Check out the latest work by the @GenomeDataLab, published in @ScienceAdvances.
➡️bit.ly/3eUx3kh
#WomenInSTEM #BigData #MachineLearning
(1/4)

Of 614 cell lines, approx. 60% greatly conserve the characteristics of the tumour of origin, another 20% maintain some resemblance. The remaining 18% differ considerably from the tumour that they supposedly represent. #IRBScience
(2/4)

@FranSupek

“Identifying cell lines that are very different from the tumour of origin is crucial because they can lead to false positive or false negative results in experiments,” says @FranSupek, head of the @GenomeDataLab at @IRBBarcelona
#IRBScience

@NatureComms

A new mechanism of toxicity in Alzheimer's disease
revealed by the 3D structure of Aβ protein assemblies out in @NatureComms.
Researchers identify specific ensembles with the capacity to disrupt the membrane of neurons, causing their death.
➡️bit.ly/3i32Ilr
#IRBScience

“Knowing the features that characterise these protein ensembles (...) is crucial to design effective therapeutic strategies that target the forms of Aβ ensembles responsible for the neurotoxicity in Alzheimer's disease,” explains Natalia Carulla, who led the study.

@Eduard_puig

“Our study suggests that some Aβ associations can perforate the membrane of neurons, alter their osmotic equilibrium, and consequently trigger their death,” say Sonia Ciudad and @Eduard_puig, first authors of the paper.

Read 3 tweets