Discover and read the best of Twitter Threads about #isoprenoids
Most recents (2)
THREAD
A little parasitology #MedEd inspired by d1 @CHOP_ID:
Diarrhea after contact with baby cows? Think #cryptosporidiosis! 💩+ 🐄 = #crypto
The other big exposure risk? Recreational water, especially pools and lakes 🏊♂️
cdc.gov/mmwr/volumes/6…
/1
A little parasitology #MedEd inspired by d1 @CHOP_ID:
Diarrhea after contact with baby cows? Think #cryptosporidiosis! 💩+ 🐄 = #crypto
The other big exposure risk? Recreational water, especially pools and lakes 🏊♂️
cdc.gov/mmwr/volumes/6…
/1
@CHOP_ID Calf exposure is such a big risk b/c calves are very likely to have #crypto. My favorite outbreak is this 2013 overturned cattle truck carrying 100s of calves. RR for diarrhea 3.0 in first responders who "carried calves":
cdc.gov/mmwr/preview/m…
/2
cdc.gov/mmwr/preview/m…
/2
@CHOP_ID T-cell immunity is important to #crypto control - think uncontrolled HIV and cyclosporin inhibitors (tacro, CsA).
First key to management - restore immune function.
Antiparasitic treatment with nitazoxanide also helpful - but often not enough if IC
cdc.gov/parasites/cryp…
First key to management - restore immune function.
Antiparasitic treatment with nitazoxanide also helpful - but often not enough if IC
cdc.gov/parasites/cryp…
Let me tell you about our newest preprint – a story of heat shock and prenylation in Plasmodium falciparum!
biorxiv.org/content/10.110…
[Thread]
Most people with malaria get fever - how do malaria parasites survive that stress? /1
biorxiv.org/content/10.110…
[Thread]
Most people with malaria get fever - how do malaria parasites survive that stress? /1
First of all, P. falciparum has a ton of heat shock proteins. In particular the DnaJ/Hsp40 family is very expanded – there are 49 Hsp40 family members in P. falciparum!! /2
Reviewed here: mdpi.com/2218-273X/9/7/…
Reviewed here: mdpi.com/2218-273X/9/7/…
We have previously found that one of these Hsp40s in Plasmodium is farnesylated – that is, modified by a 15-carbon isoprenyl group. We call it HSP40 and it is the canonical Hsp40 in malaria parasites. /3
more on the "prenylome" of malaria parasites: nature.com/articles/srep3…
more on the "prenylome" of malaria parasites: nature.com/articles/srep3…
