Discover and read the best of Twitter Threads about #isscr
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Many of the arguments shorturl.at/kDNX5 are correct but @guardian should be careful not to exaggerate statements of scientists & misinform the public. #Thread
In particular it is questionable whether scientific data that are not publicly available and thus not verifiable should be communicated in newspaper and used to make moral and ethical judgements.
#Stem cells and #EmbryoModels offer tremendous potential for understanding how we come to be and can have a very significant impact on public health. As noted in this article, they can bring profound economic, social, and environmental benefits.
Extremely excited to share our recently published paper in @Nature where we report formation of a faithful in vitro model of human blastocyst. @NRivron lab @IMBA_Vienna
A long tweetorial alert! [1/29]
nature.com/articles/s4158…
A long tweetorial alert! [1/29]
nature.com/articles/s4158…
Right starting cells necessary to form the correct model of blastocyst. We use naive ESCs, cultured in PXGL medium (developed by Austin Smith’s lab), as these are transcriptionally most similar to blastocyst epiblast; have robust potential to form all blastocyst lineages [2/29]
naive hPSC aggregates treated with inhibitors of Hippo, ERK, and TGF-β (trophectoderm formation) and human LIF (epiblast maintenance) along with ROCK inhibitor, rapidly (<96 hours) & efficiently (70-90%) form structures remarkably resembling human blastocysts [3/29]
