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A long battle for survival in a
Sars-Cov-2🦠➕Aspergillosis🦠co-infected
⚠️immunocompromised⚠️patient
(post- stem-cell transplant for leukemia)
ncbi.nlm.nih.gov/pmc/articles/P… #bioinformatics #itrtg #datascience #serverless #openscience #iot #raredisease #immunology #COVIDIsAirborne
Sars-Cov-2🦠➕Aspergillosis🦠co-infected
⚠️immunocompromised⚠️patient
(post- stem-cell transplant for leukemia)
ncbi.nlm.nih.gov/pmc/articles/P… #bioinformatics #itrtg #datascience #serverless #openscience #iot #raredisease #immunology #COVIDIsAirborne
These scenarios are unique to the
⚠️immunocompromised & immunodeficient⚠️.
If you are as such, please do EVERYTHING in your
power to avoid 🦠 Sars-Cov-2 infection:
💉vaxx ➕😷 mask ➕strategic social-📏-distancing.
⚠️immunocompromised & immunodeficient⚠️.
If you are as such, please do EVERYTHING in your
power to avoid 🦠 Sars-Cov-2 infection:
💉vaxx ➕😷 mask ➕strategic social-📏-distancing.
Kudos to teams at:
Osaka Metropolitan University Graduate School of Medicine,
Osaka, 🇯🇵 Japan,
for saving the life of this critically-ill patient. #openscience
Osaka Metropolitan University Graduate School of Medicine,
Osaka, 🇯🇵 Japan,
for saving the life of this critically-ill patient. #openscience
🆕: COVID-19🦠vaxx-💉-response in a cohort of
#immunocompromised children
organ-transplant; stem-cell transplant; rheum, +
- 2 vs 3 dose study
go.nature.com/3hERBn3 #serverless #openscience #scicomm #itrtg #iot #raredisease #datascience #immunology
#immunocompromised children
organ-transplant; stem-cell transplant; rheum, +
- 2 vs 3 dose study
go.nature.com/3hERBn3 #serverless #openscience #scicomm #itrtg #iot #raredisease #datascience #immunology
A majority of the children mounted effective humoral repsonse following 2 doses; increase to near 100% following.
Caveat: these study authors recommend a 3-dose regimen in immunocompromised pediatric patients.
Caveat: these study authors recommend a 3-dose regimen in immunocompromised pediatric patients.
Kids do ⚠️NOT⚠️ have de-facto immunity to 🦠Sars-Cov-2
*⃣ especially immunocompromised kids *⃣
I have read recent case-reports of *fatal* COVID in kids with ▪️Primary Immunodeficiency, ▪️autoimmunity, ▪️rheumatic disease, ▪️cancers, ▪️sickle-cell, ▪️transplants, and more...
*⃣ especially immunocompromised kids *⃣
I have read recent case-reports of *fatal* COVID in kids with ▪️Primary Immunodeficiency, ▪️autoimmunity, ▪️rheumatic disease, ▪️cancers, ▪️sickle-cell, ▪️transplants, and more...
🦠 ->🧠
I'm seeing a noticeable ⬆️uptick
in these disturbing reports:
#COVID19-associated psychosis in young patients
with *NO* prior history of mental-illness
publications.aap.org/pediatrics/art… #serverless #womeninstem #itrtg #scicomm #openscience #iot #neuroscience
I'm seeing a noticeable ⬆️uptick
in these disturbing reports:
#COVID19-associated psychosis in young patients
with *NO* prior history of mental-illness
publications.aap.org/pediatrics/art… #serverless #womeninstem #itrtg #scicomm #openscience #iot #neuroscience
He expressed that "the information system in his brain had been deleted,"
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."
Sars-Cov-2 🦠and ➡️ the 🧠brain
(a partial list of pathology) :
➡️ encephalitis, encephalopathy, seizures, Parkinsonism, altered consciousness, stroke, ataxia, myclonia, hallucinations, psychosis, brain hemorrhaging, vasculitis, coma...
Not just an illness of the 🫁 lungs.
(a partial list of pathology) :
➡️ encephalitis, encephalopathy, seizures, Parkinsonism, altered consciousness, stroke, ataxia, myclonia, hallucinations, psychosis, brain hemorrhaging, vasculitis, coma...
Not just an illness of the 🫁 lungs.
Relapsed/persistent
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."
sciencedirect.com/science/articl… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."
sciencedirect.com/science/articl… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology
"2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
"suggests ongoing 🦠viral persistence and replication as a driver of the lung parenchymal changes,
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.
7⃣+ months of Norovirus🦠positivity➕
in this ⚠️Primary Immunodeficiency patient
▪️ Rx-resistant
🧬-> intra-host evolution led to a unique norovirus strain
bit.ly/3RbH53d #bioinformatics #openscience #scicomm #itrtg #raredisease #genomics #immunology
in this ⚠️Primary Immunodeficiency patient
▪️ Rx-resistant
🧬-> intra-host evolution led to a unique norovirus strain
bit.ly/3RbH53d #bioinformatics #openscience #scicomm #itrtg #raredisease #genomics #immunology
Very much in line with what has been seen
in some persistent🦠Sars-Cov-2 infections in immunocompromised hosts.
▪️ viral-clearance failure
▪️ within-host viral evolution/mutations
*the report gives no indication on the fate of the patient.
in some persistent🦠Sars-Cov-2 infections in immunocompromised hosts.
▪️ viral-clearance failure
▪️ within-host viral evolution/mutations
*the report gives no indication on the fate of the patient.
⚠️Immunocompromised patients ⚠️as atypical
"outliers" with almost every🦠infectious pathogen (circa 2017).
❗️ PLEASE doctors - keep a good 👁️eye on those
with compromised immune-systems
jiac-j.com/article/S1341-… #openscience #scicomm #meded
"outliers" with almost every🦠infectious pathogen (circa 2017).
❗️ PLEASE doctors - keep a good 👁️eye on those
with compromised immune-systems
jiac-j.com/article/S1341-… #openscience #scicomm #meded
A large🆕study confirms
the⚠️danger of 🦠SarsCov2
to the #immunocompromised
Take precautions to protect yourself
cdc.gov/mmwr/volumes/7… #WomenInSTEM #openscience #itrtg #scicomm #medtwitter #immunology #raredisease
the⚠️danger of 🦠SarsCov2
to the #immunocompromised
Take precautions to protect yourself
cdc.gov/mmwr/volumes/7… #WomenInSTEM #openscience #itrtg #scicomm #medtwitter #immunology #raredisease
▪️ 💉vaxx ➕boost💉
▪️😷 mask on and up
▪️📏 practice strategic social-distancing
If you are immunodeficient or immunocompromised,
(👤LIKE ME) ... these 3⃣ things could well save your life.
▪️😷 mask on and up
▪️📏 practice strategic social-distancing
If you are immunodeficient or immunocompromised,
(👤LIKE ME) ... these 3⃣ things could well save your life.
A news article which accompanies the above research:
"Study highlights need to prioritize
immunocompromised COVID patients"
news-medical.net/news/20220710/… #WomenInSTEM #openscience #scicomm
"Study highlights need to prioritize
immunocompromised COVID patients"
news-medical.net/news/20220710/… #WomenInSTEM #openscience #scicomm
🦠Sars-Cov-2 severity and mortality has - sadly - been particularly high ⬆️among individuals with Down Syndrome.
Insightful commentary on how and why:
nature.com/articles/s4157… #WomenInSTEM #openscience #itrtg #iot #immunology #scicomm
Insightful commentary on how and why:
nature.com/articles/s4157… #WomenInSTEM #openscience #itrtg #iot #immunology #scicomm
Some earlier background on vulnerability of individuals with Down Syndrome to life-threatening COVID-19 science.org/content/articl… #openscience #scicomm
Infections and immunodeficiency in Down syndrome
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
🗓️ Published 7⃣0⃣ years ago today
The Primary Immunodeficiency world's seminal paper
"A hitherto unrecocognized entity with complete absence of gamma globulin"
publications.aap.org/pediatrics/art… #bioinformatics #openscience #scicomm #itrtg #imunology #raredisease @JPediatr @AmerAcadPeds
The Primary Immunodeficiency world's seminal paper
"A hitherto unrecocognized entity with complete absence of gamma globulin"
publications.aap.org/pediatrics/art… #bioinformatics #openscience #scicomm #itrtg #imunology #raredisease @JPediatr @AmerAcadPeds
Not the first Primary Immunodeficiency described as many think - the 3rd in fact - but the most impactful. It launched major interest in the study of these rare immune disorders.
Authored by the late Dr / Col Ogden Bruton, a legend in the Primary Immunodeficiency world.
Authored by the late Dr / Col Ogden Bruton, a legend in the Primary Immunodeficiency world.
One of my personal heroes: The late Dr / Col Ogden Bruton (right).
The immune disorder he IDd bears his name: "Bruton's Agammaglobulinemia."
(photo: circa 1954 at Walter Reed Army Hospital where he practiced as a pediatric immunologist)
The immune disorder he IDd bears his name: "Bruton's Agammaglobulinemia."
(photo: circa 1954 at Walter Reed Army Hospital where he practiced as a pediatric immunologist)
