Discover and read the best of Twitter Threads about #kidney

Most recents (8)

Why #kidney function does not equal #GFR (and certainly not Cr), making it an elusive target in clinical practice & the latter a poor surrogate outcome, despite its robust correlation with prognosis. Caring for kidneys versus improving Cr/GFR. A thread below:
The kidneys in essence have 3 functions:
1. Glomerular function = Clearance
2. Tubular function = Homeostasis
3. Neurohumoral function

GFR mainly reflects 1. So why do we take GFR (or its estimate Cr) as a surrogate for renal function?
Look at GFR determinants (=N x snGFR).

In stable circumstances, GFR mainly reflects the number of functional nephrons.

Starting from 1 million per kidney at birth, one loses 5,000-10,000 per year with aging: age-related GFR decline <1 mL/min/1.73m²/y

ncbi.nlm.nih.gov/pmc/articles/P…
Read 9 tweets
From Times: “Some 2.4 million patients have missed out on cancer tests and treatments due to a backlog caused by the coronavirus pandemic, charities have said.
According to Cancer Research UK 2.1 million patients are” awaiting screening appointments for breast, cervical and
“bowel cancer and another 290,000 have not had referrals for tumours. It is also estimated that about 21,600 patients have had surgery, chemotherapy or radiotherapy postponed in the past nine weeks.
Sarah Woolnough, policy chief at Cancer Research UK, warned that hospitals faced“
a “huge backlog to clear”. She told the Daily Mail: “It’s a massive backlog of services and treatment to deliver. It’s absolutely huge, it’s thousands and thousands.”
A No Deal #Brexit will make backlog even worse. Add #diabetes #epilepsy #kidney patients to the list= Seismic!
Read 6 tweets
#Breaking #Breaking News
CLASS ACTION LAWSUIT against #BillGates #vaccine Maker #Gilead maker of #Remdesivir for DELIBERATELY Hiding Side Dangerous Damaging Effects & withholding better drugs they had responsibility to inform & change to, harming MILLIONS of people ON PURPOSE.
2/
CORRUPT #Gilead has been Sued MANY TIMES now for their CORRUPT Anti-human actions DELIBERATELY hiding new more safe less risky & less damaging treatments ON PURPOSE knowing they will damage people FOR OVER 10 YEARS. They now DEMAND your Blind Trust as does #BillGates & #Fauci
3/
All #HIV patients & EVERYONE who knows someone with HIV is advised to IMMEDIATELY contact the lawfirm of Miller & Zois at 800-553-8082 so they can check their eligibility for a LARGE NUMBER of #medicalmalpractice Lawsuits that may help them get some #Justice & @FBI u shud look
Read 11 tweets
#Remdesivir begins distribution in the #USA today via #EUA.

I thought would write down some practical #tips based on my #qualitative anecdotal experience after personally treating close to 200 patients with #COVID19.

For quantitative results, wait for the papers¬—thread
“this juice works, doc!” When you hear similar expressions 1-2 days after starting #remdesivir multiple times, you start to wonder. Don't recall a similar proportion of patients smile after feeling so sick 1-2 days earlier with #COVID19. x/n? Wait for the papers.
Like #treatment for any severe infectious disease (meningitis, Gram-negative bacteremia, influenza pneumonia, etc), earlier is always better. #COVID19 is no different. #Remdesivir stops #SARS-CoV2 replication, but won’t heal the lung injury.
Read 13 tweets
1/ Inspired by this exchange between @kidney_boy and @dreliotheher, here is my first ever #tweeetorial: the issues with the current #kidney allocation system in the U.S., based mainly on the work of @SumitMohanMD and Jesse Schold, and inspired by my jetlag #KidneyTransplant
@kidney_boy @dreliotheher @SumitMohanMD 2/ >100,000 patients on the kidney waiting list. Each year, >10K die or removed from the wait list without a transplant. Those who do not get a transplant have worse survival, quality of life, and cost to health care system. optn.transplant.hrsa.gov/data/view-data…
@kidney_boy @dreliotheher @SumitMohanMD 3/ Q: What % of kidneys procured FOR THE PURPOSE OF TRANSPLANTATION is not used for a transplant?
Read 19 tweets
Hey #tipsfornewdocs #medtwitter folks! I wanted to review side effects of immune checkpoint inhibitors (ICIs) for a non-#oncology audience. Immune-related adverse events (irAEs) present across all medicine specialties so we are all in this together. 1/x
The most common ICIs are against PD-1 (e.g. nivolumab, pembrolizumab) and PD-L1 (e.g. atezolizumab, durvalumab). I use a blanket term “PD-1” throughout. Anti-CTLA-4 (ipilimumab) is a distant second; often in combo or directly after PD-1 in #melanoma #lung #kidney cancers. 2/x
They have led to pharma riches and Nobel Prizes and lots of TV commercials because they work really well for some patients. People with advanced #melanoma, #lcsm etc who used to live ~1 year now can hope to live for several years or more. 3/x
Read 17 tweets
Today is #WorldKidneyDay, so here is a thread about living on #dialysis & #OrganDonation. My name is Belinda Otas. I’m #African. I’m #Nigerian. I'm #Benin. I’m #British & I’m #Black. Beyond the nationalities or passports with my name, I also believe in our shared humanity.
I was 16, when I was diagnosed with End Stage Renal Failure (ESRF.) I had no idea what was happening to me because at the time, it made no sense. However, I remember the pain of that period like noonday. I lived on dialysis until i was 22. #dialysis #OrganDonation #renalhealth
It took over my teenage years. I don’t remember having much of a life as a teenager because dialysis was 3x a week & every session was 4hrs. Add the time it takes to recover from being exhausted by the process, my day was pretty much over. #dialysis #OrganDonation #renalhealth
Read 70 tweets
This looks to be fun look at renal research around the world. I made my picks the way I make my picks at a horse track - I went by the titles. I expect as with #nephmadness as the results come in I'll learn why my picks were wrong and then more about the research that advances.
@RSNhope @ihatedialysis @KidneyPatients @DialysisAtHome @hdunews this is a new social media "game" that pits various renal research studies from around the world against each other in a World Cup style competition. This is a fun
gateway to the world of renal research
We with CKD should familiarize ourselves with the language of research and what is now being worked on so that as opportunities arise to engage we will be prepared to contribute #kidneyresearch #dialysis #kidney
Read 3 tweets

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