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So excited to finally share this work - structure of Cx46/50 gap junction intercellular channels in a dynamic lipid environment, resolved at 1.9 Å by #CryoEM! With some MD-simulation to make it dance ;) Check it out on BioRxiv: shorturl.at/iEW34
Lead by an extraordinary team of grad/undergrad students: Jonny Flores (@CryoEMJonny), Bassam Haddad (@BassBioPhys), Kim Dolan and Janette Myers – and our wonderful collaborators Craig Yoshioka (@craigky), Jeremy Copperman and Dan Zuckerman @psu_research, @OHSUSOM
We see a stunning effect of Cx46/50 on the local lipid environment - effectively inducing a phase separation (to the gel state) that is specific to the extracellular lipid leaflet of the two opposed membranes
