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A #tweetorial from @RossLevineLab and colleagues on our new preprint online today at @biorxivpreprint from @sloan_kettering biorxiv.org/content/10.110…
1. The cohesin complex is comprised of structural proteins (Smc1a, Smc3, Rad21) bound to a Stag protein (most commonly Stag1 or Stag2). The entire complex is targeted by somatic mutations in myeloid malignancies, whereas STAG2 is most prevalent across all cancer @cohesin_papers
2. We & others have described that the core cohesin complex regulates hematopoietic self renewal & differentiation. However the fundamental biologic mechanism remained unclear & the unique role of Stag2 in gene regulation, hematopoiesis & transformation was not known.
