Discover and read the best of Twitter Threads about #l1000
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1/ Our contribution to drug repositioning (DR) for metabolic disease (MD)
In HUMANS Insulin resistance (IR) in muscle & adipose shares COMMON molecular pathways & COMMON treatment responses (n= >2,000 samples). @mackinprof @eLIFE @JPTK_TechBio @chvolmar
doi.org/10.7554/eLife.…
In HUMANS Insulin resistance (IR) in muscle & adipose shares COMMON molecular pathways & COMMON treatment responses (n= >2,000 samples). @mackinprof @eLIFE @JPTK_TechBio @chvolmar
doi.org/10.7554/eLife.…
2/ Using the common molecular features from muscle & adipose we built a 120-gene RNA IR assay & found this multi-gene assay could rank families of active drugs by potency #novel Active drugs have many protein targets #not-novel
@mackinprof @eLIFE
doi.org/10.7554/eLife.…
@mackinprof @eLIFE
doi.org/10.7554/eLife.…
3/ The assay identified >200 +ve & -ve acting drugs – many proven to improve or impair insulin signalling. Not all +ve drugs will be safe to explore further but many had efficacy in recent MD models @mackinprof @eLIFE
doi.org/10.7554/eLife.…
doi.org/10.7554/eLife.…
