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In a new paper led by @annasimsbiol, we find that influenza infections divide your throat into tiny territories, and ask:
why don’t these viruses want to be friends?

Paper doi.org/10.1371/journa…
Commentary doi.org/10.1371/journa…

A 🧵 An image showing two infected regions, one green and one mag
Some background: If two viruses get into the same cell, they can genes exchange (basically they can breed). This is really important for viral evolution. A dramatic example is when different strains of influenza A virus (IAVs) use coinfection to generate pandemic strains A schematic showing a green and magenta virus coinfecting a
Many viruses actively push back against coinfection, changing an infected cell until it becomes resistant to infection by related viruses. This effect is known as ‘superinfection exclusion’ (SIE) A schematic showing a cell infected by a green virus which,
Read 23 tweets
In a new preprint led by @annasimsbiol, we ask:
Why Don’t These Viruses Want to be Friends?
A 🧵...
biorxiv.org/cgi/content/sh… An image showing two infected regions, one green and one mag
Coinfection is an important aspect of viral evolution. If two viruses can get into the same cell, they can undergo genetic exchange. A dramatic example of this is when different strains of influenza A virus (IAVs) use coinfection to generate novel pandemic strains A schematic showing a green and magenta virus coinfecting a
However, many viruses actively push back against coinfection. In a variety of ways, they change an infected cell until it becomes resistant to infection by related viruses. This effect is known as superinfection exclusion (SIE) A schematic showing a cell infected by a green virus which,
Read 17 tweets

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