Discover and read the best of Twitter Threads about #lceconsortium
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We are really excited to share our work on how Pervasive lesion segregation shapes cancer genome evolution @biorxivpreprint.
Here’s a #tweetorial to explain our #LesionSegregation findings...
biorxiv.org/content/10.110…
Thread, 1/11
Here’s a #tweetorial to explain our #LesionSegregation findings...
biorxiv.org/content/10.110…
Thread, 1/11
Human cancer genomes are unavoidably confounded by genetic and environmental differences. Such intrinsic heterogeneity confounds our ability to disentangle biases of DNA damage and repair. So we used an in vivo oncogenesis model to re-run cancer evolution hundreds of times.
2/11
2/11
WGS of these mutagen-initiated tumours had a high burden of point mutations, comparable to cancers caused by exogenous mutagens, eg lung and skin cancer. The tumours are dominated by Thymine mutations - the “DEN signature” - and driver mutations in the EGFR/RAS/RAF pathway.
3/11
3/11
