Discover and read the best of Twitter Threads about #ldlbounty
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1/ Interesting timing, @LDLSkeptic -- @siobhan_huggins and I are coauthoring a post that lays out the "lipoprotein-centric" vs "lipid profile-centric" schools of thought.
But since this has come up a lot in the last 24 hours, I'll do a twitter thread on the overview...
But since this has come up a lot in the last 24 hours, I'll do a twitter thread on the overview...
2/ Almost everyone takes the "lipoprotein-centric" view of risk. That is to say, most believe there's a particular lipoprotein metric to watch for. The troublemaker, as it were.
For conventional medicine, that's all ApoB-containing lipoproteins (remnants and LDL, of course)...
For conventional medicine, that's all ApoB-containing lipoproteins (remnants and LDL, of course)...
3/ For many in the low carb space it's a subset of LDL. Specifically, the "small dense" particles, rather than the "large buoyant" particles with the latter generally considered safe.
Also, and related, many point to oxidized LDL (oxLDL) or glycated LDL as the true troublemaker.
Also, and related, many point to oxidized LDL (oxLDL) or glycated LDL as the true troublemaker.
@AviBittMD @Jevan @RocknRolloff As you know, I don't quickly jump to hit the Causality Proven Button anyway. ;)
But that said, when something is shown to associate with greater ACM in every context found at a stepwise dose dependent level, I consider that compelling. The key is to look for every context...
But that said, when something is shown to associate with greater ACM in every context found at a stepwise dose dependent level, I consider that compelling. The key is to look for every context...
@AviBittMD @Jevan @RocknRolloff Hence my interest in [high LDL + high HDL + low TG] (Low carb lipid triad).
@AviBittMD @Jevan @RocknRolloff Thus far, the #LCCholesterolChallenge hasn't been met yet and I haven't put out the #LDLBounty. But maybe you, @AviBittMD, will be the one to collect. ;)
cholesterolcode.com/lccholesterolc…
cholesterolcode.com/lccholesterolc…
1/ Today marks my 18 month-aversary since beginning the #LCCholesterolChallenge cholesterolcode.com/lccholesterolc… and exactly a year ago adding #LDLBounty to meet the challenge. To date, I've only found studies showing the opposite -> High LDL+High HDL+Low TG = Low cardiovascular disease..
2/ The reason I say "best study" in the challenge instead of "any study" is that I thought it may well be possible there were tens if not hundreds of studies that might meet the definition. Again, I've only found the opposite, like this one: ncbi.nlm.nih.gov/pubmed/27166203
3/ The colored overlays are mine, to emphasize this "triad" of high LDL, high HDL, and low triglycerides... 
1/ The anniversary of the #LDLBounty will be in a couple weeks. I'm still seeking to gather non-drug/non-gene studies showing a triad of high LDL+high HDL+low triglycerides=high cardiovascular disease. Thus far, I've only seen studies showing the opposite.
2/ This is extremely relevant to #keto/#lchf given this triad of rising LDL, rising HDL, and dropping triglycerides is a very common outcome. Of course, if you follow my work, you know I consider this more likely due to being powered by fat (metabolic) than disease (pathologic)
3/ After six months with no submissions, and on the anniversary of the original #LCCholesterolChallenge, I brought the finder's fee up higher to $1,000 with a $3,000 budget.
