Discover and read the best of Twitter Threads about #lenalidomide
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Our first paper authors.elsevier.com/a/1cRqD6tu0Cbo… is now out @CellStemCell! With @ionispharma & the Jamieson Lab @UCSanDiegoDRM, we found that selective #antisense oligonucleotides inhibiting #IRF4 reduce disease burden & #multiplemyeloma #regeneration in #cancer models. @CellPressNews 1/ 
IRF4 (interferon regulatory factor 4) is a key plasma cell transcription factor that is known to play a critical role in #myeloma progression. It's been shown to activate networks of #cellcycle and cancer regulators, including the notorious #cancer and #stemcell gene, #MYC. 2/
In this new work, the talented @PhoebeMondala & @AshniVora first dug deeper into the IRF4 networks activated in high-risk forms of #myeloma, including #plasmacellleukemia. IRF4 target genes (SLAMF7, BCMA) were widely induced, especially among genes regulating the #cellcycle. 3/
Tweetorial #5: the interesting origin of the CBL gene. This story will take us to Spanish California and the world of murine retroviruses… and C.P. “Dusty” #Rhoads of refractory anemia fame will even make a brief cameo appearance. This image is a ribbon diagram of CBL. #CBL /1
In the winter of 1812, a series of San Andreas earthquakes struck southern California, destroying the original church at San Juan Capistrano and damaging several other 'Las Californias' missions. There were also tsunamis, which would have made coastal living less appealing./2
After the earthquakes, a number of people living near the 9th Franciscan mission, "San Buenaventura", in present-day Ventura, California, withdrew from the immediate coast & temporarily moved inland to higher ground in another part of what is now Ventura County #VenturaCounty./3
