Discover and read the best of Twitter Threads about #leusm

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#Tweetorial Just finished 4 weeks on the leukemia service at @UCCancerCenter. We saw a number of patients present with a new diagnosis of acute leukemia and hyperleukocytosis, our index of concern for the development of leukostasis was dependent on if they had AML or ALL.
In 1982 Lichtman et al wrote about hyperleukocytic leukemias. The leukocrit (packed WBC volume) was described in AML, ALL, and CLL. Due to the larger mean cell volume of myeloblasts, a higher leukocrit was observed in AML compared to ALL and CLL.
The pathophysiology of leukostasis is thought to be driven in part by blood viscosity. A higher leukocrit and hematocrit correlates with a higher blood viscosity.
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Our viewpoint JUST OUT in @NatRevClinOncol on the role (or lack thereof) of blinatumomab for B-ALL in complete remission #leusm nature.com/articles/s4157…
We present 4 points to think about when considering the use of blinatumomab for B-ALL in CR. I have a feeling Vinay Prasad (@PlenarySessShow), may have a few things to say about it. nature.com/articles/s4157…
1/ the methods of MRD testing are not universally agreed upon and have variable sensitivities. What is sometimes considered "negative" by one method may not be "negative" by another. bloodjournal.org/content/125/26…
Read 9 tweets

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