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Excited to share our work on subcutaneous administration of hydrophobic, vesicant anticancer drugs via water-soluble polymer prodrugs out in @J_A_C_S Wonderful team effort! @ERC_Research @UnivParisSaclay @CNRS @INC_CNRS @CNRSIdFSud @Pharma_UPSaclay doi.org/10.1021/jacs.2…
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👉 Chemotherapy is almost exclusively administered intravenously (IV) which has serious limitations:
➡️Patient discomfort (central route🩸, catheter failure…)
➡️Frequent hospital stays🏥, trained staff🩺👨⚕️needed…
➡️Costly (and cost will 📈 as new cancer cases will 📈)
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➡️Patient discomfort (central route🩸, catheter failure…)
➡️Frequent hospital stays🏥, trained staff🩺👨⚕️needed…
➡️Costly (and cost will 📈 as new cancer cases will 📈)
🧵2/n
What about other administration routes?
➡️Oral route 💊: very restrictive. Low and variable bioavailability. Chemo requires precise dosing.
➡️Subcutaneous (SC) route 💉: not possible for vesicant/irritant drugs because of skin ulceration 🚨 and even necrosis ☠️
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➡️Oral route 💊: very restrictive. Low and variable bioavailability. Chemo requires precise dosing.
➡️Subcutaneous (SC) route 💉: not possible for vesicant/irritant drugs because of skin ulceration 🚨 and even necrosis ☠️
🧵3/n
