Discover and read the best of Twitter Threads about #lncrna

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MALAT1 & NEAT1

Long Non Coding RNAs, Lymphoma and COVID

Interesting paper on new potential biomarkers for aggressive lymphomas, LncRNAs.

It highlights the LncRNAs involved in lymphoma.

There are some similar LncRNAs dysregulated by COVID. > https://onlinelibrary.wiley...
> https://onlinelibrary.wiley...Image
> https://onlinelibrary.wiley...Image
Read 10 tweets
It became the major allele in wolves, making them bigger than other canids, probably during the last ice age. However, the small allele never disappeared.
During the #domestication time, humans created the first small dogs using the ancestral small allele that still existing in wolves. We found it in a 9,500 year old dog sample. Today this small allele is the major allele in modern dogs, in 75% of small breeds < 15kg
We also show that the mutation is located within a #lncRNA, antisense of IGF1, sharing 182 bp in common, that we named IGF1-AS. We did not detect differential expressions for IGF1 and IGF1-AS between large and small #dogs, but we measured difference in IGF1 protein level in serum
Read 4 tweets
Excited to share our story about an ancestral mutation in a #lncrna antisense of IGF1, that appeared over 50,000 years ago in #wolves, and that impacts modern #dogs and wild canids body size. It's out in @CurrentBiology. cell.com/current-biolog…
All thanks to my co-authors including @NicolasDubos @BevantKevin @ThomasDerrien7 @laurenhennelly1 @LrFrantz @Greger_Larson and the Ostrander lab @genome_gov
It is not only a #dog story, it is a #canid story.
An old allele associated with small size is shared between 13 different canid species.
A second allele, associated with large size, appeared in #wolves lineage, detected in a 54,000 years old #wolf.
Read 7 tweets

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