Discover and read the best of Twitter Threads about #loopextrusion
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Proud of this collaboration, getting to the bottom of the links between chromatin mobility, #transcription control and #loopextrusion processes, now on bioRxiv:
biorxiv.org/content/10.110…
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@mitchell_lab @tinekelenstra @EviSoutoglou @molina_lab @AkisPapantonis @kerstinbys
biorxiv.org/content/10.110…
1/8
@mitchell_lab @tinekelenstra @EviSoutoglou @molina_lab @AkisPapantonis @kerstinbys
We tagged the Sox2 promoter and enhancer for their simultaneous tracking in live ES cells. While the two elements were frequently close , this distance remained largely unchanged on different means of inhibiting gene transcription.
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More importantly, we found that the promoter and enhancer were significantly less mobile than control regions. This was predicted by molecular dynamics simulations, taking loop extrusion and transcription factor-mediated clustering into account.
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