Discover and read the best of Twitter Threads about #lymphocytopenia
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SARS-CoV-2 contains a novel nuclearization sequence PRRARSV in the spike protein. This is equivalent to the Simian Immunodeficiency Virus SV 40 TAg. Both the spike protein itself and mRNA are found to translocate to the nucleus.
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
Here is general information SV 40 TAg from Wikipedia. The protein is ideal for studying nuclearization signals.
en.wikipedia.org/wiki/SV40_larg…
en.wikipedia.org/wiki/SV40_larg…
The spike is imported into the nucleus with importin a.
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
NEW: Clinical course and outcomes of critically ill patients with #SARSCoV2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study thelancet.com/lancet/article…
#COVID19 #Coronavirus
#COVID19 #Coronavirus
Of 710 patients with #SARSCoV2 pneumonia, 52 critically ill adult patients were included. The mean age of the 52 patients was 59·7 (SD 13·3) years, 35 (67%) were men, 21 (40%) had chronic illness, 51 (98%) had fever
32 (61·5%) patients had died at 28 days, and the median duration from admission to the intensive care unit (ICU) to death was 7 (IQR 3–11) days for non-survivors
