Discover and read the best of Twitter Threads about #m1ψ

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Developing an #mRNA vaccine is a sure-shot way to success? No! Despite the spectacular performance of #Pfizer & #Moderna vaccines, we also have a #CureVac fiasco. We need to dig in much deeper into the intricacies of developing a highly efficacious mRNA vaccine 1/
There is more than low dose & impact of VOCs behind #CureVac’s failure. And here we once again need to salute the sheer brilliance of @kkariko . Will do a little thread to explain, why! 2/
No doubt, the #CureVac used a much lower #RNA dose. Dose is lower (12 (CureVac) vs 30 (#Pfizer) vs 100 ug (#Moderna)) but no idea how that translates to protein. Need to know how much of a role the lower dose played in the lower efficacy 3/
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