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I predict that so-called more selective mTORC1 inhibitors will have equal or inferior antiaging effects compared with #rapamycin. I predict that maximal anti-aging effect will be achieved with a combination of high doses of rapamycin plus low doses of pan-mTOR inhibitors
such as Torin-1, which can inhibit rapamycin-insensitive functions of #mTORC1. But doses must be low to avoid inhibition of other kinases and side effects. Thus High rapamycin plus Low pan-mTOR inhibitor
All my previous predictions were confirmed
ncbi.nlm.nih.gov/pubmed/20436272
ncbi.nlm.nih.gov/pubmed/20436272
