Discover and read the best of Twitter Threads about #mTORi
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1/ Continuing the #immunosuppression #tweetorial series...@MedTweetorials
Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors
Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.
It was isolated from a soil sample from which island in 1975?
Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors
Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.
It was isolated from a soil sample from which island in 1975?
2/ Meet mTOR, a phosphatidylinositol 3-kinase (PI3)-related kinase (adds a phos). mTOR adds a phosphoryl group to serine/threonine residues.
It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
3/ mTOR inhibition blocks "Signal 3" of #TCell activation - reducing cytokine dependent cell proliferation and activation.
Take a look at all 3 signals below 👇🏽
nejm.org/doi/full/10.10…
Take a look at all 3 signals below 👇🏽
nejm.org/doi/full/10.10…
