Discover and read the best of Twitter Threads about #mainprotease
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SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity
Top #NSP5 (MPro) mutations: H164N, G15S, T135I
Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.
1/n
Top #NSP5 (MPro) mutations: H164N, G15S, T135I
Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.
1/n
Mpro mutations associated with reduced nirmatrelvir activity (≥3-fold higher Ki values): G15S (4.4-fold), T135I (3.5-fold), S144A (91.9-fold), H164N (6.4-fold),
H172Y (233-fold), Q189K (65.4-fold), and D248E (3.7-fold).
fda.gov/media/155050/d…
2/n
H172Y (233-fold), Q189K (65.4-fold), and D248E (3.7-fold).
fda.gov/media/155050/d…
2/n
Omicron-MPro-Pax-Tracker: (by sublineage, by state/division, by county/location):
3/n
public.tableau.com/app/profile/ra…
3/n
public.tableau.com/app/profile/ra…
