Discover and read the best of Twitter Threads about #mainprotease

Most recents (1)

SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity

Top #NSP5 (MPro) mutations: H164N, G15S, T135I

Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.

1/n
Mpro mutations associated with reduced nirmatrelvir activity (≥3-fold higher Ki values): G15S (4.4-fold), T135I (3.5-fold), S144A (91.9-fold), H164N (6.4-fold),
H172Y (233-fold), Q189K (65.4-fold), and D248E (3.7-fold).

fda.gov/media/155050/d…

2/n
Omicron-MPro-Pax-Tracker: (by sublineage, by state/division, by county/location):

3/n
public.tableau.com/app/profile/ra…
Read 13 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!