Discover and read the best of Twitter Threads about #manuscriptmonday
Most recents (6)
Tell-All Volvelle?
Newly re-cataloged to include the movable bits! This hand-drawn "Viennese Oracle" dial points you to one of 16 riddles and presumably, THE TRUTH!
#ManuscriptMonday #interactive
1/4
@NewberryLibrary
i-share-nby.primo.exlibrisgroup.com/permalink/01CA…
Newly re-cataloged to include the movable bits! This hand-drawn "Viennese Oracle" dial points you to one of 16 riddles and presumably, THE TRUTH!
#ManuscriptMonday #interactive
1/4
@NewberryLibrary
i-share-nby.primo.exlibrisgroup.com/permalink/01CA…
@NewberryLibrary Behold!
Worthy of the Oracle at Delphi, is it not? All that nearly grisaille watercolor marbling to establish a German Romantic nostalgia vibe in the process of using the dial...
2/4
Worthy of the Oracle at Delphi, is it not? All that nearly grisaille watercolor marbling to establish a German Romantic nostalgia vibe in the process of using the dial...
2/4
@NewberryLibrary Wisdom of the Ages?
Looks like the book is getting a ringing endorsement from Athena and her owl! I presume the dial is around the back of the monument? I'm unfamiliar with Joseph Dietrich, but he signed all the pictures...
3/4
Looks like the book is getting a ringing endorsement from Athena and her owl! I presume the dial is around the back of the monument? I'm unfamiliar with Joseph Dietrich, but he signed all the pictures...
3/4
1/ The Laws of Hywel Dda – a #ManuscriptMonday thread!
The Laws of Hywel Dda were a system of native Welsh laws named after and thought to be first codified by Hywel Dda (d.950), king of Deheubarth 👑
The Laws of Hywel Dda were a system of native Welsh laws named after and thought to be first codified by Hywel Dda (d.950), king of Deheubarth 👑
2/ One of the earliest surviving Latin copies is Peniarth MS 28 (mid-13thC), which includes a series of colourful illustrations accompanying the text.
Decoration such as this was very rare in Welsh-produced manuscripts of the time: hdl.handle.net/10107/4400109
Decoration such as this was very rare in Welsh-produced manuscripts of the time: hdl.handle.net/10107/4400109
3/ The Black Book of Chirk, also dating from the mid-13thC, provides one of the earliest surviving examples of the Laws written in Welsh.
The manuscript, perhaps written as a practical text, contains very little decoration: hdl.handle.net/10107/5719618
The manuscript, perhaps written as a practical text, contains very little decoration: hdl.handle.net/10107/5719618
Thinking about rubrication and manuscripts. I feel like I ought to build a Tampermonkey or Greasemonkey script that takes initial capitals online and makes them large, red, even historiated /illuminated.
Or perhaps something that converts the CSS of @Hypothes_is highlights and makes the letters red instead of having a yellow background? #EdTech
A bit reminiscent, but of a different historical period than the index card idea.
A bit reminiscent, but of a different historical period than the index card idea.
What if we had a collection of illuminated initials and some code that would allow for replacing capitals at the start of paragraphs we were reading?
1/#ManuscriptMonday #IDTwitter #Tweetorial
Does oral vanco ppx during systemic abx therapy prevent healthcare facility-onset C. diff infection in high-risk patients?
@MannyGuajardoMD recently reviewed a study on this very topic at our virtual JC.
pubmed.ncbi.nlm.nih.gov/31560051
Does oral vanco ppx during systemic abx therapy prevent healthcare facility-onset C. diff infection in high-risk patients?
@MannyGuajardoMD recently reviewed a study on this very topic at our virtual JC.
pubmed.ncbi.nlm.nih.gov/31560051
2/Healthcare facility-onset C diff infection (HCFO-CDI) is ️💰🤒☠️
What can we do to prevent HCFO-CDI?
✅Inf prevention strategies
✅#AntimicrobialStewardship
❓Probiotics
❓OVP
What can we do to prevent HCFO-CDI?
✅Inf prevention strategies
✅#AntimicrobialStewardship
❓Probiotics
❓OVP
3/Downsides to OVP:
💊Affects GI microflora
💊VRE overgrowth 📈
💊Increased risk for C. diff colonization
💊Not always tolerated
💊Cost effective?
pubmed.ncbi.nlm.nih.gov/31560048/
💊Affects GI microflora
💊VRE overgrowth 📈
💊Increased risk for C. diff colonization
💊Not always tolerated
💊Cost effective?
pubmed.ncbi.nlm.nih.gov/31560048/
#ManuscriptMonday: Fostemsavir is a first-in-class investigational HIV-1 attachment inhibitor being studied in treatment-experienced PLWH with multiple mutations and limited ART options
Fostemsavir:
🔸oral, +/- food
🔸prodrug of temsavir, which binds directly to gp120
Fostemsavir:
🔸oral, +/- food
🔸prodrug of temsavir, which binds directly to gp120
2/BRIGHTE trial @NEJM :
Phase 3 trial in 23 countries
Enrolled 371 pts with MDR HIV into 2 cohorts
🔸Cohort 1 (N=272): patients w/ 1-2 active drug options left
🔸Cohort 2 (N=99): no remaining ART options
DOI: 10.1056/NEJMoa1902493
Phase 3 trial in 23 countries
Enrolled 371 pts with MDR HIV into 2 cohorts
🔸Cohort 1 (N=272): patients w/ 1-2 active drug options left
🔸Cohort 2 (N=99): no remaining ART options
DOI: 10.1056/NEJMoa1902493
3/Study design:
🔸Cohort 1➡️randomized 3:1
Day 1-8: add on fostemsavir (600mg BID) or placebo to failing regimen (blinded)
Day 8 onward: open-label fostemsavir + optimized background therapy (OBT)
🔸Cohort 2➡️non-randomized
Day 1 onward: open-label fostemsavir + OBT
🔸Cohort 1➡️randomized 3:1
Day 1-8: add on fostemsavir (600mg BID) or placebo to failing regimen (blinded)
Day 8 onward: open-label fostemsavir + optimized background therapy (OBT)
🔸Cohort 2➡️non-randomized
Day 1 onward: open-label fostemsavir + OBT
1/7 #ManuscriptMonday! 📄 Let’s talk about chloroquine and hydroxychloroquine, which were recently FDA-approved for treatment of COVID-19. There has been a lot of hype and misinformation surrounding the drugs. One particular study by Gautret et al. ⬇️ was published...
2/7 ...in the International Journal of Antimicrobial Agents, and tweeted by President Trump as “one of the biggest game changers in the history of medicine.” Since then, patients who take the drugs for other reasons, such as rheumatoid arthritis or lupus...
3/7 ...have had trouble accessing them due to others stockpiling the medication for their own, off-label use. One American has died and another has been hospitalized due to self-medication with chloroquine phosphate. Many scientists have called the results of the study...
