Discover and read the best of Twitter Threads about #mast
Most recents (2)
@jenbrea Hey! Yes several people spoke on that topic at the recent #ILADs conference I was at 👉 and remember this case history which found that a woman treated w/ antibiotics to target persistent #Bartonella had substantial improvement in EDS symptoms: ncbi.nlm.nih.gov/pmc/articles/P…
@jenbrea 2/2 As for #mast cell activation in response to persistent #pathogens...there is extensive literature on how a range of bacterial, viral and fungal pathogens can drive #MCAS-like symptoms 👉 for example: ncbi.nlm.nih.gov/pmc/articles/P…
@jenbrea 3/3 There is even a receptor common in #connective tissue who’s activity controls mast cell activation in response to bacterial signaling molecules that drive #biofilm formation: ncbi.nlm.nih.gov/m/pubmed/31278… 
This study (in mice) found that quorum sensing peptides created by #bacteria 👉 could bind a host mast-cell-specific G-protein coupled receptor☝️in a manner that triggered #mast cell degranulation, but inhibited bacterial growth + biofilm formation: cell.com/cell-host-micr…
In simple terms the study provides early evidence that mast cell degranulation (associated w/ #MCAS) 👉 can be driven by bacterial signaling molecules tied to biofilm formation: cell.com/cell-host-micr…
2/2 This adds to the possibility that, in #MCAS, mast cells are not activated for “unexplained reasons” 👉 Rather (at least in some cases)☝️they are activated in response to communities of organisms/#pathogens in the human body...or the molecules such organisms create
