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(1/n) Excited that final version of work led by @D4N__ studying evolutionary repeatability and collateral sensitivity is out. #mathevo #clecliniccancer nature.com/articles/s4146… @CCLRI @NatureComms @CWRUSOM
(2/n) This collab between @CompSciOxford @CCLRI @CWRUSOM & @MoffittPSOC is an extension of @D4N__ ‘s initial theory paper that proposed ‘steering evolution’ as a method of extending the use of existing drugs to control infection. #AntibioticResistance journals.plos.org/ploscompbiol/a…
(3/n) using the fitness landscape metaphor, we reasoned that instances of collateral sensitivity need not be repeatable, as evolutionary branch points could lead to multiple peaks - which could have different sensitivity profiles.
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