Discover and read the best of Twitter Threads about #mcid
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I have spoken about the importance of minimally clinically important differences (#MCID)
before in relation to sample sizes but how do you decide what it should be? There was an interesting paper published this week adding to this literature 1/8
#MethodologyMonday
before in relation to sample sizes but how do you decide what it should be? There was an interesting paper published this week adding to this literature 1/8
#MethodologyMonday
The MCID drives the sample size - it is the minimum clinically important difference you set your trial to detect. Set the MCID too small and the sample size will be much larger than needed; but make the MCID too big & your trial will miss clinically important effects 2/8
There are different methods of calculating #MCIDs - the DELTA project is a great resource in this regard. 3/8
DELTA: journalslibrary.nihr.ac.uk/hta/hta18280/#…
DELTA: journalslibrary.nihr.ac.uk/hta/hta18280/#…
