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How do we show mutation? A #sciart thread…🧵
I’ve illustrated the #SARSCoV2 spike protein a lot over the last few years, including its mutations. In the process, I made many decisions about how to show mutations, and wanted to share my rationale. (1/12)
I’ve illustrated the #SARSCoV2 spike protein a lot over the last few years, including its mutations. In the process, I made many decisions about how to show mutations, and wanted to share my rationale. (1/12)
First, it’s important to review how we describe mutations - they’re identified in reference to an original, un-mutated reference sequence. (2/12)
So, for example, D614G means: “The amino acid at position 614 that was a D (aspartic acid) is now a G (glycine) in the mutated spike.”
D614del would mean: “The amino acid at position 614 that was a D is now missing in the mutated spike.” (3/12)
D614del would mean: “The amino acid at position 614 that was a D is now missing in the mutated spike.” (3/12)
