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2 brothers in their 30’s presented to us with progressive Cerebellar ataxia. On examination, there is slightly restricted vertical gaze.

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#MedTwiter #NeuroTwitter #Neurology
One of the typical features of Niemann-Pick C disease is SUPRANUCLEAR VERTICAL GAZE PALSY

Ataxia, Dystonia Psychomotor Regression are common

GELASTIC CATAPLEXY is another common feature
The disease follows an Autosomal Recessive inheritance and unlike A/B, C can present in older ages with neurological features, without hepatosplenomegaly
Read 9 tweets
#mmsm Hematologica published 3 articles for sub-group analysis for Isatuximab recently:
1-IKEMA pts with renal failure-Full article
2- ICARIA-MM elderly pt-letter to editor
3-IKEMA+ICARIA-MM: 1q-letter to editor
πŸ›‘All used 1-2 medical writers
Was this all the story ? 🧡
Same medical writers helped in a review of key subgroup analysis of ICARIA-MM πŸ‘‡

Also in doing another subgroup analysis in high risk cytogenetics
You think we are done: NO

ICARIA-MM subgroup analysis πŸ‘‡

Expert review article with the help of medical writer πŸ‘‡
Read 12 tweets

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