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I am pleased & proud to see the #PLUStrial published in @NEJM today. It is my 10th @NEJM paper! Here’s my list of @NEJM papers and what I think they mean for clinical practice
#1: The #HEATtrial (Dec 2015) showed that using paracetamol to treat fever in ICU patients with suspected infections did not affect the number of ICU-free days. Mortality rates were similar in paracetamol & placebo-treated patients:
nejm.org/doi/full/10.10…
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These data provide reassurance that if paracetamol is administered to treat fever in the setting of an infection or given for another reason to a patient who happens to have fever & infection, such as for analgesia, harm is unlikely to result.
The #ICUROXtrial has been published today in @NEJM. The 1st author (and our #ICUROXtrial project manager extraordinaire) is @dianemackle
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
This #tweetorial is to highlight what we did, what we found, what I think is means, & what next.
We enrolled 1000 mechanically ventilated adults who were anticipated to require ventilation in ICU beyond the calendar day after randomisation.
