Discover and read the best of Twitter Threads about #membranes

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#Haemolysis data indicates that #disruption of host cell #membranes by rotating #flagella is physically possible, despite what previously published measurements with firing gold nanobeads at tissue cultures tells us.

[Pls read the paper for the more complex story with E.coli]
But what if #flagella did penetrate host cell #membranes? What might that mean?
Well, in vitro at least, #Ecoli and #Salmonella #flagella can enhance #actin #polymerization rates. Interactions with #Cofilin-1 (CFL) had an additive effect... Actin polymerisation rates with flagella from E. coli (H6, H
Read 8 tweets
8 years since the first manuscript draft but it's finally here!

The interaction of #Ecoli O157β€Š:H7 and #Salmonella Typhimurium #flagella with host cell #membranes and cytoskeletal components | #Microbiology #Pathogenesis #Thread

microbiologyresearch.org/content/journa…
@strain9000 @ArielBlocker @MicrobioSoc This all started many πŸŒ‘πŸŒ’πŸŒ“πŸŒ”πŸŒ•πŸŒ–πŸŒ—πŸŒ˜πŸŒ‘ ago...

Jo Elvidge and I were looking at the role of #flagella in early infection of #Salmonella and #Ecoli in relevant animal tissue models (πŸ–πŸ„)

We spotted what looked like very intimate adherence... E.coli O157:H7 on Bovine terminal rectal cellsSalmonella Typhimurium on porcine epithelial cells
It was a toughie to quantify back then with the tools we had, but every time we looked, we saw it πŸ€“
Read 9 tweets

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