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Tan CC, Eckardt KU, Ratcliffe PJ. Organ distribution of erythropoietin messenger RNA in normal and uremic rats (1991) doi.org/10.1038/ki.199โ€ฆ EPO mRNA was measured in the kidneys of unstimulated control animals and was detectable, at lower levels, in the liver and lung #mEPO ๐Ÿ’‰
After exposure to hypoxia, there was a 150-fold increase in renal mEPO. Hepatic EPO mRNA was also greatly increased and accounted for 39% of the total. A small quantity of EPO mRNA was in lung. Animals subjected to subtotal nephrectomy became uremic and anemic. Letโ€™s compare๐Ÿ’‰๐Ÿ‘‡ ImageImageImageImage
EPO protein is a secreted protein that is easily measured in serum by enzyme-linked immunosorbent assay. EPO stimulates red blood cell creation that can be measured using a hematocrit assay. EPO mRNA is available to model your secreted protein calling mEPO trilinkbiotech.com/products-serviโ€ฆ
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