Discover and read the best of Twitter Threads about #mercytrial

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We've just presented and published a multicenter RCT at #CCR23 and in @JAMA_current!

Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial!

🔗 jamanetwork.com/journals/jama/…

This 🧵 will explain the study in detail /11

#FOAMcc Image
2/

β-lactams (e.g., #meropenem), are typically given intermittently, but continuous administration can provide constant serum levels and may improve outcomes.

In fact, several meta-analyses reported reduced mortality when administered continuously. Image
3/

Therefore, we conducted a multinational, double-blind, randomized controlled trial to test the hypothesis that continuous administration of #meropenem, compared with intermittent administration, would improve clinically relevant outcomes in critically ill pts with #sepsis Image
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