Discover and read the best of Twitter Threads about #mercytrial
Most recents (1)
We've just presented and published a multicenter RCT at #CCR23 and in @JAMA_current!
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial!
🔗 jamanetwork.com/journals/jama/…
This 🧵 will explain the study in detail /11
#FOAMcc
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial!
🔗 jamanetwork.com/journals/jama/…
This 🧵 will explain the study in detail /11
#FOAMcc
2/
β-lactams (e.g., #meropenem), are typically given intermittently, but continuous administration can provide constant serum levels and may improve outcomes.
In fact, several meta-analyses reported reduced mortality when administered continuously.
β-lactams (e.g., #meropenem), are typically given intermittently, but continuous administration can provide constant serum levels and may improve outcomes.
In fact, several meta-analyses reported reduced mortality when administered continuously.
3/
Therefore, we conducted a multinational, double-blind, randomized controlled trial to test the hypothesis that continuous administration of #meropenem, compared with intermittent administration, would improve clinically relevant outcomes in critically ill pts with #sepsis
Therefore, we conducted a multinational, double-blind, randomized controlled trial to test the hypothesis that continuous administration of #meropenem, compared with intermittent administration, would improve clinically relevant outcomes in critically ill pts with #sepsis
