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1. Our work showing that GABA-receptive microglia selectively sculpt inhibitory synapses during development is out @CellCellPress: authors.elsevier.com/c/1dMWhL7PXe~wk
Wonderful collaboration w/ @stevens1lab @Datta_Lab Farhi lab @RichBonneauNYU @harvardmed @broadinstitute thread⬇︎
2. Work from many labs has shown that #microglia are key regulators of synapse #development but we know that not all #synapses are created equal. The best example? Excitatory vs inhibitory synapses. Are microglia a jack of all trades or do they focus on specific synapse types?
3. At the outset, we were unsure whether microglia even regulate the development of inhibitory synapses. The answer to this was "they do”. When we depleted microglia during cortical development, we observed increases in both excitatory and inhibitory synapses
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