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Voici un site qui regroupe une FAQ de questions courantes qui reviennent sur notre méta-analyse sur l'hydroxychloroquine et nous avons décidé d'y répondre

➡️ metahcq.wordpress.com

Notre publication : doi.org/10.1016/j.cmi.…

#metaHCQ Ă  partager
Le sommaire des articles sur la méta-analyse et sur des questions plus générales d'épidémiologie/recherche clinique

RĂ©cemment l'American College of Cardiology Ă©crivait sur notre article : "This meta-analysis summarizes the latest findings from studies examining the impact of HCQ Image
and AZI on mortality in patients with COVID-19. Findings are consistent with the prior studies showing no positive impact of HCQ treatment in COVID-19. This meta-analysis delves into subgroup analyses and explores potential sources of heterogeneity,
Read 5 tweets
📍BUCKLE UP—huge HYDROXYCHLOROQUINE & #COVID19 meta-analysis of all useable trials & observational studies w/ 30,000—11,932 participants on HCQ, 8,081 on HCQ+azithromycin & 12,930 control. ➡️ Result? Big fat null. Trials or not. HCQ+azithro even worse! 🧵 clinicalmicrobiologyandinfection.com/article/S1198-…
2) HCQ didn’t lower mortality— Relative Risk RR=0.83 (95% CI: 0.65-1.06, n=17 studies) for all studies and RR=1.09 (95% CI: 0.97-1.24, n=3 studies) for trials alone. The RR=0.83 but confidence intervals 0.65-1.06 overlapping 1 (no effect) means the results were not significant.
3) For HCQ+azithromycin, the results were even worse: Hydroxychloroquine with azithromycin was associated with an increased mortality: RR=1.27 (95% CI: 1.04-1.54, n=7 studies), meaning 27% increased risk (significant because CI didn’t overlap 1).
Read 18 tweets

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