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Diseases of ageing are quite distinct from conventional diseases with a genetic basis - revealsed by the incidence profile with age #MethuselahHealth 
Diseases of ageing occur because the machine wears out rather than because one of the components was faulty. Ageing is a property of the system not its parts…
EVERYONE ages, no matter what your genome!
#MethuselahHealth
EVERYONE ages, no matter what your genome!
#MethuselahHealth
The paradigm for pharma has become the “genetically-validated target” - which has proved excellent at fixing diseases caused by defective parts (mostly the “rare diseases”). But it totally fails in the prevalent age-related diseases, where the system falls apart
I agree. Complement misregulation is key to understanding #covid19 symptomatic variations
This chimes with our work at #MethuselahHealth - where we have uncovered complement regulation as a key player in ageing. Around 50yo we see significant “innate autoimmunity” as proteome errors accumulate and trigger self-recognition
This in turn results in a suppression of complement to prevent “self-immolation”, so reducing protection against infections. But these changes in complement balance also mean that when rampant infection does occur the amount of collateral damage is much greater in the elderly
