Discover and read the best of Twitter Threads about #methylpred
Most recents (1)
It’s been a busy couple of nights in the ICU. Normally I’d be asleep right now, but I’m pumped to talk about #steroids in #COVID19.
A Brief Thread on #steroids in #COVID19.
(Spoiler alert: more compelling RCTs show that steroids work!)
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A Brief Thread on #steroids in #COVID19.
(Spoiler alert: more compelling RCTs show that steroids work!)
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Early in the pandemic it was unclear if steroids would be beneficial or harmful.
There were studies that steroids could reduce mortality in ARDS (DEXA-ARDS), but also studies showing that they could prolong viral shedding in related viruses (MERS).
Clear equipoise for RCTs.
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There were studies that steroids could reduce mortality in ARDS (DEXA-ARDS), but also studies showing that they could prolong viral shedding in related viruses (MERS).
Clear equipoise for RCTs.
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This changed in June, when the #RECOVERY trial (bit.ly/2QKCSGJ) found an impressive mortality decrease in patients treated with #dexamethasone.
This large, well designed study almost immediately changed practice. But a few questions lingered..
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This large, well designed study almost immediately changed practice. But a few questions lingered..
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