Discover and read the best of Twitter Threads about #microdosing
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Here is my breakdown of the new #psychedelic #microdosing paper published yesterday (tinyurl.com/mrbhk3xd) that was 🔥🔥🔥 since all these flyers were going around at the wonderland meeting👇🍄💊🚨 
Healthy males were randomised into LSD (n=40) and placebo (n=40) groups. They received 14 doses of either 10μg LSD or placebo every 3 days for 6 weeks.
Participants were naïve to MDing, but 70% in both groups had prior psychedelic experience (last use over a year ago), so by in large this was NOT a psychedelic naïve sample.
1/ #Oregon Health Authority publishes latest draft #psilocybin rules to implement Measure 109. Some early thoughts: First, the rules allow for a variation of #microdosing. Clients could consume up to 5mg and potentially leave a center after 1 hour.
oregon.gov/oha/PH/PREVENT…
oregon.gov/oha/PH/PREVENT…
2/ Under the draft rules, the minimum length of administration sessions would vary based on the dose of #psilocybin received. Clients consuming 5 - 10mg could potentially leave after 2 hours, and 15 - 25mg would require a minimum stay of 4 hours.
3/ The facilitator to client ratios will also change depending on the doses of #psilocybin received, ranging from a potential 8 clients to each facilitator for doses of 5 - 10mg to no more than 1 client for every facilitator for doses between 40 - 50mg.
Time for another #sciencetwitter journal club! Today's paper: #Microdosing with #psilocybin #mushrooms: a double-blind placebo-controlled study by Cavanna et al 2022! Hot off the presses!
nature.com/articles/s4139…
nature.com/articles/s4139…
This study has:
34 participants, about half of which had previous experience with psychedelics
Randomized, double-blind placebo-controlled, within-subjects design
0.5. g psilocybin mushroom in capsule and edible, non-psychedelic mushroom as placebo
34 participants, about half of which had previous experience with psychedelics
Randomized, double-blind placebo-controlled, within-subjects design
0.5. g psilocybin mushroom in capsule and edible, non-psychedelic mushroom as placebo
typical "microdose" is 0.1 - 0.5 g of dried mushrooms, which still can produce some type of altered consciousness, hallucination effect depending on the person.
most common regimen is 1 day on 2 days off, based on Fadiman's work.
most common regimen is 1 day on 2 days off, based on Fadiman's work.
Does blinding work in #antidepressant #RCT? Recently there were 2 papers on this topic with opposite conclusions. A🧵on #blinding and why #robustness #DataAnalytics may lead to better #science
The two papers are tinyurl.com/2p9atk4t (p1; by @AmeliaJScott, @LSharpeUSYD and @BenColagiuri) and tinyurl.com/mtmtx7m3 (p2; by @Toshi_FRKW and colleagues).
Their two conclusions:
-p1: "meta-analysis suggested that blinding was unsuccessful among participants and investigators."
-p2: "patients or assessors were unlikely to judge which treatment the patients were on."
-p1: "meta-analysis suggested that blinding was unsuccessful among participants and investigators."
-p2: "patients or assessors were unlikely to judge which treatment the patients were on."
1/5 If you’re enjoying @michaelpollan’s #HowToChangeYourMind on @netflix and want to go deeper on the science, here’s a list of #psychedelic readings authored by @DiamondThera advisors, collaborators and team members:
2/5 @DiamondThera advisor Dr. Torsten Passie’s book delves into the scientific literature on #microdosing. It covers tolerance, toxicity, and placebo and surfaces research that is often overlooked.
amazon.ca/Science-Microd…
amazon.ca/Science-Microd…
3/5 A 360 review of available evidence on #psychedelic compounds’ effects on the pathways modulating neuroplasticity, immunity, and neurotransmitter systems. By @DiamondThera collaborators Dr. Gabriella Gobbi and Danilo De Gregorio. pubmed.ncbi.nlm.nih.gov/33328244/
1/ @michaelpollan's highly-expected @netflix series #HowToChangeYourMind just premiered! 📺🍄 Despite near-universal praise, #HTCYM is rife with errors & borders on historical revisionism 🤥
A critique 🤔🧵 #LSD #MDMA #Peyote #Mescaline #Psilocybin #Mushrooms #Psychedelic @MAPS
A critique 🤔🧵 #LSD #MDMA #Peyote #Mescaline #Psilocybin #Mushrooms #Psychedelic @MAPS
2/ Before I get started, I'll give everyone a little bit of background information. @michaelpollan released a non-fiction work entitled "How to Change Your Mind" in May of 2018. Before the end of that year, his book about #psychedelic drugs became a @nytimes bestseller.
3/ @michaelpollan achieved massive coverage for this self-described "mental travelogue" of his #psychedelic experiences. Soon enough, Mr. Pollan became a prominent figure w/in the so-called "Psychedelic Renaissance". In the process, he gained a rather interesting reputation.
Despite the importance of #blinding in medical research, most trials don't assess blinding integrity, partially because there is no method to adjust trial results for blinding integrity... until now! New preprint with implications for #microdose and #psychedelic research 🧪🧵👇
First, we define activated expectancy bias (AEB), which is an uneven distribution of expectancy effects between treatment arms due to patients recognizing their treatment allocation. AEB can be viewed as residual expectancy bias not eliminated by the trial’s blinding procedure.
The main idea behind AEB is that if treatment allocation can be deduced by participants, then, treatment expectancy can bias the outcomes in the same manner as it biases non-blinded trials, for example as in open-label trials.
So, I thought I’d microdose this morning, get some errands done, you know. End of the year type stuff. Nope. I’m going NO WHERE. Physically anyways. Downside to organic = unpredictability.
#psychedelics #magicmushrooms #microdosing #depression
#psychedelics #magicmushrooms #microdosing #depression
Man, inter-planetary travel IS possible. Every time I stand up and my blood pressure drops, I’m off to a whole new world.
Right now, I’m on an ice world.
I have to get up and clean the cat crapper pretty soon. It’ll be an adventure as to where I’ll actually end up! 🤪
I have to get up and clean the cat crapper pretty soon. It’ll be an adventure as to where I’ll actually end up! 🤪
