Discover and read the best of Twitter Threads about #micrornas
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Very happy to see our microRNA metastases paper out. co-led by @HyeEirik and by many fantastic colleagues
We show the reasons for previously published contradicting reports of de-regulated #microRNAs in colorectal cancer #tumors and #metastases:
tinyurl.com/yckwdk2z
We show the reasons for previously published contradicting reports of de-regulated #microRNAs in colorectal cancer #tumors and #metastases:
tinyurl.com/yckwdk2z
Among them are
- lack of correction for background expression
- different metastatic sites were not analyzed as separate entities
- expression cut-off level for microRNAs to ensure biological relevance are typically not used
- lack of correction for background expression
- different metastatic sites were not analyzed as separate entities
- expression cut-off level for microRNAs to ensure biological relevance are typically not used
We establish a stringent, reproducible and easily expandable bioinformatics pipeline (github.com/eirikhoye/mirn…) that we applied on all previously published (depending on availability) and a large range of novel smallRNA sequencing datasets, altogether 268 datasets.
On 10/27/21 Daniel Tillett @Nucleics_Inc exposed problems with theories linked to obesity drug development via announcement of collaboration with Dan Dominissini who linked #SNPs in #microRNAs to viral latency via publication of "Single base resolution mapping..." 11/22/18
ncbi.nlm.nih.gov/labs/pmc/artic… "... we have developed Nm-seq, which could identify 2'OMe sites at single base resolution." The link from energy-dependent changes in #SNPs in #microRNAs to biophysically constrained viral latency attests to facts that compelled Daniel Tillett to attack.
Intelligent serious scientists from Israel, Iran, and Korea have linked light-activated carbon fixation in cyanobacteria from the physiology of pheromone-regulated reproduction to the patent for biophysically constrained viral latency. See for example: onlinelibrary.wiley.com/doi/10.1002/ac…
Final version of our Ancient microRNA paper out with @RNAJournal out today. We are very happy to see our manuscript online and hope you all enjoy it as we do :-).
A thread on RNA from 14 000 year old samples 1/6
#Paleotranscriptomics rnajournal.cshlp.org/content/27/3/3…
A thread on RNA from 14 000 year old samples 1/6
#Paleotranscriptomics rnajournal.cshlp.org/content/27/3/3…
When reading the great study by Smith et al on the #Tumatpuppy ancient RNA sequencing that used a smallRNA sequencing protocol, we immediately thought to dig deeper in their data for #microRNAs. 2/6 journals.plos.org/plosbiology/ar…
Teaming up with them and @CpgSthlm (@love_dalen), we found microRNAs that showed abundances and nucleotide damage patterns (!) comparable to what had been described from historic, but never before from such ancient, >14 000yrs old RNA samples 3/6 
📢🎉The work of #Bat1K is featured on the cover in the latest issue of @nature: “Six reference-quality #genomes reveal evolution of #bat adaptations” 🦇🧬 #bats Our thread 👇 on the paper:nature.com/articles/s4158… 📸: Olivier Farcy(1/n)
📢Have you ever wondered how 🦇 manage to do what they do? #bats have extraordinary adaptations, including powered #flight, laryngeal #echolocation, #vocal #learning and an exceptional #longevity with unique #immunity and resistance to #cancer! 📸: @DanielWhitby5 (2/n)
A #Bat1K team led by @Sonja_Vernes @EmmaTeeling1 @hillermich @TheGeneMyers has just published the raw genetic material that codes for these unique 🦇 adaptations and #superpowers in @nature! #bats #genomics #cool! (3/n)
